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Sudden unexpected death in epilepsy (SUDEP) is the most important directly epilepsy-related cause of death, with an estimated incidence of 1.2 cases per 1,000 adult epilepsy patients per year [1]. Some risk factors were identified including longstanding epilepsy and frequent generalized tonic-clonic seizures [1], but it is still challenging to estimate the individual SUDEP risk. The fatal cascade leading to SUDEP mostly involves primary central apnea following generalized tonic-clonic seizures [2].