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Although numerous new antiepileptic drugs (AEDs) have been introduced over the last decades, offering advantages in terms of tolerability and drug interactions, most clinical trials and meta-analyses have failed to demonstrate any significant superiority in terms of efficacy of these newer AEDs as compared to older AEDs. [1–3] Also, it is well established that seizure response rates to add-on AED treatment decrease with subsequent AED trials [4–6]. For these reasons, overall drug response rates in patients with epilepsy have not increased significantly over the last decades [7,8].