Long-term seizure outcomes in patients with drug resistant epilepsy

Although numerous new antiepileptic drugs (AEDs) have been introduced over the last decades, offering advantages in terms of tolerability and drug interactions, most clinical trials and meta-analyses have failed to demonstrate any significant superiority in terms of efficacy of these newer AEDs as compared to older AEDs. [1–3] Also, it is well established that seizure response rates to add-on AED treatment decrease with subsequent AED trials [4–6]. For these reasons, overall drug response rates in patients with epilepsy have not increased significantly over the last decades [7,8].