Sulthiame add-on therapy in children with Lennox-Gastaut syndrome: A study of 44 patients

Lennox-Gastaut syndrome (LGS) is a paediatric epilepsy syndrome described as a triad consisting of multiple seizure types, such as tonic –mostly occurring at night–, atonic, and atypical absence seizures, intellectual disability or regression, and abnormal electroencephalography (EEG) findings with a symptom onset before 12-24 months of age [1]. The EEG abnormalities consist primarily of an interictal pattern of diffuse, slow spike-wave complexes at 2.5 Hz during wakefulness and paroxysmal fast rhythms (10–20 Hz) during sleep, mainly in the non-rapid eye movement phase, which is the hallmark of tonic seizures [1].