Cross-sensitivity of Psychiatric and Behavioral Side Effects with Antiepileptic Drug Use

It is well established in the literature that psychiatric and behavioral side effects (PBSE) are common in patients using antiepileptic drugs (AED) [1–4]. These adverse effects can range from minor behavioral changes to debilitating depressive symptoms and even suicidality [1–6]. PBSEs may oftentimes lead to discontinuation of medication, and it has been reported by several studies that previous psychiatric history is a highly important independent predictor of PBSE incidence in epilepsy patients using AEDs [1–4].

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