Analysis of fractional anisotropy and mean diffusivity in refractory and non-refractory idiopathic generalized epilepsies

Idiopathic generalized epilepsy (IGE) patients usually present normal neuroimaging findings and adequate seizure control if treated with an appropriate antiepileptic drug regimen. Abnormalities in conventional neuroimaging in IGE patients usually represent incidental findings, not related to epilepsy pathophysiology. A significant minority of IGE patients present breakthrough seizures despite appropriate treatment [1]. These patients usually receive higher antiepileptic drug loads.

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