It was with great interest that we read the recent publication of Meng-Na Zhang et al. in this periodical, reporting the pharmacoresistant epilepsy in patients (aged 3 months to 10 years old) with tuberous sclerosis complex (TSC) presenting calcification in the cerebral parenchyma [1]. The authors concluded that calcification in the epileptic foci is one of the main reasons for this pharmacoresistance to anti-epilepsy drugs and rapamycin, an inhibitor of the mTOR signaling pathway (often overactivated in TSC).
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