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Antiepileptic drugs (AEDs) play a vital role in epilepsy management. Despite ample experience with two generations of AEDs, current medications still fail to control seizures in 20-30% of all epilepsy patients [1,2]. Temporal lobe epilepsy (TLE), especially when lesional, is often associated with drug resistance [1,3,4]. Patients with mesial temporal sclerosis (MTS) are more likely to develop drug-refractory epilepsy [1,5]; although one third of patients in the general TLE population develops drug resistance, the proportion is twice as high in patients with MTS.