Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy

Depression is highly common in patients with epilepsy, with a prevalence of approximately 30% in patients with recurrent seizures [1]. Depression not only negatively affects patient quality of life but is also correlated with cognitive functioning in patients with epilepsy [2,3]. However, the mechanisms underlying the comorbidity of epilepsy and depression remain unclear. Evidence from clinical and laboratory research indicates that there are common pathogenic mechanisms associated with epilepsy and depression [4].