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Epilepsy is the most common serious neurological disease. Although the majority of patients suffering from epilepsy are well-managed with anti-epileptic drugs (AEDs), approximately 30% of people affected by epilepsy still have recurrent seizures and are drug resistant, which can result in a progression to intractable epilepsy (IE) [1–4]. Patients with intractable temporal lobe epilepsy are usually excellent candidates for epilepsy surgery, which is efficacious in up to 70% of cases [5]. IE can give rise to serious clinical problems.