Un grupo de 4 centros hospitalarios españoles encabezados por la Fundación Jimenez Días ha publicado en el número de Febrero de la revista Epilepstic Disorders un artículo en el que destaca la eficacia de la zonisamida en el tratamiento de 13 pacientes con epilepsia generalzada idiopática. Aprobada para su uso como terapia concomitante en los pacientes con crisis parciales con o sin generalziacion secudnario, contínua su esfuerzo en documentar su eficacia en las crisis generalziadas.
Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy. Marinas A, Villanueva V, Giráldez BG, Molins A, Salas-Puig J, Serratosa JM. Fundación Jiménez Díaz, Madrid, Hospital La Fe, Valencia, Hospital Josep Trueta, Girona, Hospital Central de Asturias, Oviedo, Spain.Epileptic Disord. 2009 Feb 27
Objective. The objective of this study is to evaluate the efficacy and safety of zonisamide (ZNS) for the treatment of idiopathic generalized epilepsies (IGEs). Methods. Thirteen patients with different types of IGEs who were treated with ZNS between the years 2006 and 2008 were identified. Efficacy and tolerability were assessed at months 6 and 12 post-treatment. Response was defined as a 50% or greater reduction in seizure frequency. Results. Twelve patients (92.3%) continued with ZNS at month 6, and 11 (84.6%) at month 12. Mean daily dose was 319 mg (range 100-500 mg/d). Response was achieved at month 6 in eight of the 12 patients that continued with ZNS (66.6%), of which 7 were seizure-free (58.3%). At month 12, eight of the 11 patients that continued with ZNS were responders (72.7%) and 6 were seizure-free (63.6%). For different types of seizures, better responses were observed for absences and generalized tonic-clonic seizures. Four out of 13 patients (30.7%) experienced adverse events and in two (15.3%), these led to withdrawal. Conclusion. In this retrospective study, ZNS showed efficacy and tolerability for the treatment of different types of IGEs. Limitations include a small sample size and a relatively short period of follow-up. Our results are promising and justify the need for prospective controlled trials in IGE.
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