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As one of the most prevalent chronic neurological condition characterized by the recurrence of unprovoked seizures, epilepsy is afflicting seventy million people worldwide, with 50.4 per 100,000 people newly diagnosed every year [1]. In clinical practice, the final goal of epilepsy management is to help patients attain complete seizure freedom with the minimal side effects of antiepileptic drugs (AEDs) [2]. Previous studies have indicated that the high frequency of seizures before appropriate AEDs therapy, poor response to initial AEDs therapy, specific epilepsy syndromes might suggest a worse outcome [3–5].