New-onset refractory status epilepticus (NORSE) is a syndrome of prolonged seizures that typically develops in otherwise healthy, young individuals without a history of epilepsy or obvious initial cause. The term was first coined in a case series of 7 young women with prior good health who developed refractory status epilepticus (RSE) with an extensive, negative diagnostic work-up and poor outcome [1]. While the incidence of RSE is estimated between 9–43% of all episodes of SE, no such data exists for NORSE [2,3].
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