Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

Concern about climate change amongst the general public is acknowledged by surveys. The healthcare sector must play its part in reducing greenhouse gas emissions and adapting to a changing climate, which will require the support of its stakeholders including those with epilepsy who may be especially vulnerable. It is important to understand this community’s attitudes and concerns about climate change and societal responses.

Methods

A survey was made available to over 100,000 people amongst a section of the neurological community (patients, carers ...

Abstract

Catamenial epilepsy is the best described and most researched sex-steroid specific seizure exacerbation. Yet despite this there are no current evidence based treatments nor an accepted diagnostic tool. The best tool we can currently have is tracking seizures over menstrual cycles however the reality of tracking seizures and menstrual cycles is fraught with challenges. In Part 1 (citation to be added on publication) of this two-part review we outlined the often complex and reciprocal relationship between seizures and sex steroids. ...

Abstract

Objective

Epilepsy with generalized tonic–clonic seizures alone (GTCA) is a common but poorly characterized idiopathic generalized epilepsy (IGE) syndrome. Hence, we investigated electroclinical features, seizure outcome, and antiseizure medication (ASM) withdrawal in a large cohort of GTCA patients.

Methods

In this multicenter retrospective study, GTCA patients defined according to the diagnostic criteria of the International League Against Epilepsy (2022) were included. We investigated prognostic patterns, drug resistance at the last visit, and ASM withdrawal, along with their prognostic factors.

Results

We included 247 patients with ...

Abstract

Objectives

While in epilepsy patients the likelihood of becoming seizure-free decreases substantially with each unsuccessful treatment, to our knowledge this has been poorly investigated in status epilepticus (SE). We aimed to evaluate the proportion of SE cessation and functional outcome after successive treatment steps.

Methods

We conducted a post-hoc analysis of a prospective, observational, multicenter cohort (SENSE), in which 1049 incident adult SE episodes were prospectively recorded at 9 European centers. We analyzed 996 SE episodes without coma-induction before the third treatment step. ...

Abstract

Objective

The National Childhood Vaccine Injury Act of 1986 created the National Vaccine Injury Compensation Program (VICP), a no-fault alternative to the traditional tort system. Since 1988, the total compensation paid exceeds $5 billion. While epilepsy is one of the leading reasons for filing a claim, there has been no review of the process and validity of the legal outcomes given current medical information. The objectives were to review the evolution of the VICP program in regard to vaccine-related epilepsy and ...

Abstract

Although animal models have helped to elaborate meaningful hypotheses about the pathophysiology of Sudden Unexpected Death in Epilepsy (SUDEP), specific prevention strategies are still lacking, potentially reflecting the limitations of these models and the intrinsic difficulties of investigating SUDEP. The interpretation of pre-clinical data and their translation to diagnostic and therapeutic developments in patients thus require a high level of confidence in their relevance to model the human situation.

Preclinical models of SUDEP models are heterogeneous and range from rodent and ...