The epileptogenic zone in pediatric epilepsy surgery: Special Issue

Intractable epilepsies in infants and children have enduring, far-reaching consequences for psychomotor and social development. Early epilepsy surgery for patients who are surgical candidates can have an immeasurably positive impact on their lives. To this end, I am excited to present this Special Issue of Seizure authored by forty-two experts to discuss the important topic of pediatric epilepsy surgery. Even before a child is considered for epilepsy surgery, assessment of all children who present with a first seizure begins with ...

Seguir leyendo →
0

Open-label, uncontrolled retrospective study of perampanel in adults with Lennox-Gastaut syndrome

The Lennox-Gastaut syndrome (LGS) is a recognizable form of epileptic encephalopathy characterized by multiple etiologies, multiple seizure types, cognitive deterioration, extensive electroencephalographic (EEG) changes awake and asleep, and resistance to antiepileptic drug (AED) treatment [1–3]. The long-term evolution of LGS is characterized by the possible abatement of EEG changes, especially awake, and by the persistence of invalidating seizures [4]. Traditional pharmacological options include valproate (VPA) and a combination of VPA and lamotrigine (LTG) [2].

Seguir leyendo →
0

A single-center, retrospective analysis of genotype-phenotype correlations in children with Dravet syndrome

Initially described by Dr. Charlotte Dravet over 30 years ago [1], Dravet syndrome (OMIM #607208) is an infantile-onset epileptic encephalopathy associated with global developmental delays and intractable epilepsy. Hallmarks of the disease include initial normal development and seizure onset typically in the first year of life, consisting of prolonged generalized or unilateral clonic seizures often following a febrile illness or vaccination. Subsequent intractable epilepsy comprises multiple seizure types (generalized tonic-clonic, alternating hemiconvulsive, absence, myoclonic, and other focal seizures) that often ...

Seguir leyendo →
0

Early versus late antiepileptic drug withdrawal following temporal lobectomy

Freedom from antiepileptic drugs (AEDs) is an important goal of epilepsy surgery and patients usually consider themselves cured only when the AEDs are completely withdrawn. [1,2] Although this issue of AED withdrawal following epilepsy surgery is very important to patients, there is relative dearth of data about the AED usage following epilepsy surgery. The practice of AED withdrawal varies across the centers and clinicians remain sharply divided in their practice of AED management following epilepsy surgery [3–5].

Seguir leyendo →
0

Status Epilepticus Special Edition

One of the rare joys of compiling a special edition for a Journal is being able to write a more informal prologue. On putting this collection of manuscripts together, I was reminded of a comment made to me by a rather portly, now rather famous, London nephrologist while I was a junior doctor. Over a mouthful of lunch, he told/ instructed me that there were only two things that necessitated running from the canteen. The first was a cardiac arrest, ...

Seguir leyendo →
0

Insomnia symptoms and obesity are associated with aggression independent of depression in patients with epilepsy

Aggression can be defined as “overt motor behavior enacted with the intent to do harm or injury to a person or object, with the expectation that harm will occur” [1]. Interictal aggression related to epilepsy has been well described in the literature and is not a new concept. Although interictal dysphoric disorder, a mood disorder found in persons with epilepsy (PWE), has been a matter of debate [2], a symptom cluster characterized by periodical mood changes and outbursts of irritability ...

Seguir leyendo →
0

New-onset refractory status epilepticus: a retrospective cohort study

Status epilepticus (SE) is a neurological emergency with more than 180 described causes; common causes include medication change or noncompliance in patients with known epilepsy, toxic-metabolic disturbances, sedative/hypnotic withdrawal, acute/remote stroke, and brain tumor [1]. The term new-onset refractory SE (NORSE) is applied to a patient without a prior diagnosis of epilepsy or other preexisting relevant neurological disorder, with new onset of refractory SE (RSE) that does not respond to first- and second-line antiseizure drugs and no clear acute or ...

Seguir leyendo →
0

Socioeconomic outcome and access to care in adults with epilepsy in Sweden: a nationwide cohort study

An association between socioeconomic status (SES) and epilepsy has been demonstrated in both insurance-based and public health-care systems. A US survey in 2010 by the Centre for Disease Control and Prevention demonstrated that the prevalence of active epilepsy is 1% in the US, but 1.9% in low-income US households [1]. A geographical correlation between socioeconomic deprivation and prevalence of epilepsy has been disclosed in the UK [2]. Data also indicate that SES is associated with the severity of epilepsy.

Seguir leyendo →
0
Página 5 de 86 «...34567...»