Electroencephalography after a single unprovoked seizure

Electroencephalography (EEG) remains an essential diagnostic tool in the evaluation of seizure disorders. The most recent clinical guidelines from the American Academy of Neurology for both children [1] and adults [2] recommend that an EEG be obtained after a single unprovoked seizure. Indeed, EEG abnormalities may be useful in identifying epileptogenic foci, structural abnormalities, and/or electrographic patterns associated with specific epilepsy syndromes. However, it is the potential predictive value of EEG that can have the most prominent role in the ...

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Electroencephalography after a single unprovoked seizure

Electroencephalography (EEG) remains an essential diagnostic tool in the evaluation of seizure disorders. The most recent clinical guidelines from the American Academy of Neurology for both children [1] and adults [2] recommend that an EEG be obtained after a single unprovoked seizure. Indeed, EEG abnormalities may be useful in identifying epileptogenic foci, structural abnormalities, and/or electrographic patterns associated with specific epilepsy syndromes. However, it is the potential predictive value of EEG that can have the most prominent role in the ...

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Emergency computed tomography in patients with first seizure

Among patients presenting with first seizure (FS) to emergency department (ED), the challenge for the evaluating physician is to identify patients with acute symptomatic seizures. Formally, an acute symptomatic seizure is defined as a clinical seizure occurring at the time of a systemic insult or in close temporal association with a documented brain insult [1]. Pragmatically, acute symptomatic seizures are symptoms of a condition deserving immediate attention and treatment, such as stroke or central nervous system infection.

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Psychiatric Comorbidities in New Onset Epilepsy: Should they be always investigated?

The new definition of epilepsy establishes that epilepsy is not only a disorder presenting with epileptic seizures but it can be often associated with cognitive and psychiatric comorbidities. In fact, the prevalence of psychiatric comorbidities is relatively high in patients with epilepsy (PWE), as one in three patients will have experienced a psychiatric disorder in the course of their life, with mood and anxiety disorders being the most frequent.Psychiatric comorbidities often precede the onset of the seizure disorder, and affect ...

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Genetic generalized epilepsy in three siblings with 8q21.13-q22.2 duplication

Duplication of chromosome region 8q21.13-q22.2 is a rare abnormal copy number variant (CNV) previously reported in a few patients. Although these reports have mentioned the presence of seizures, the description was vague and an electroclinical syndrome has not been delineated [1–3]. Herein, we aimed to outline the epilepsy phenotype associated with 8q21.13-q22.2 duplication adding a new genetic finding to the spectrum of genetic generalized epilepsies (GGEs). Ethics approval was granted by the University Health Network Research Ethics Board.

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Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model

Epilepsy is the most common serious neurological disease. Although the majority of patients suffering from epilepsy are well-managed with anti-epileptic drugs (AEDs), approximately 30% of people affected by epilepsy still have recurrent seizures and are drug resistant, which can result in a progression to intractable epilepsy (IE) [1–4]. Patients with intractable temporal lobe epilepsy are usually excellent candidates for epilepsy surgery, which is efficacious in up to 70% of cases [5]. IE can give rise to serious clinical problems.

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