Corrigendum to “A single-center, retrospective analysis of genotype–phenotype correlations in children with Dravet syndrome” [Seizure: Eur. J. Epilepsy 75 (2020) 1–6]

The authors regret that several of the SCN1A variants reported in the supplementary table were annotated incorrectly per chart reports, and appreciate the assistance of the HGMD editors in correcting these variants. In the Results section, p.Ala1442Val should be noted as p.Ala1440Val, and p.Phe1761Thrfs*8 should be noted as p.Phe1671Thrfs*8. Appropriate corrections to all other variants are provided in updated supplementary tables (see attachment) verified through sequence alignment to the cDNA RefSeq for transcript variant 1 of SCN1A (NM_001165963.4) and original ...

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Seizure and Sudden Unexpected Death in Epilepsy (SUDEP) characteristics in an urban UK intellectual disability service

Intellectual disability (ID) is defined as a significant impairment of intellectual function and adaptive behaviour, developing before 18 years of age [1]. People with ID have higher rates of morbidity and mortality than those without ID [2,3]. The reasons for this are multifactorial and range from higher prevalence of co-morbidity to barriers accessing suitable services [4,5].

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Evaluation of wait times for assessment and surgical intervention according the geographic area of residence in the province of Saskatchewan, Canada

Epilepsy is a highly prevalent chronic neurological disease with more than 50 million people affected worldwide [1,2]. Prevalence rates in Canada are 5 cases/year per 1000 people[3]. The inherent unpredictability of seizure occurrence contributes to impaired physical, cognitive and emotional well-being [4]. Health-related Quality of Life (QOL) is lower in persons with epilepsy (PWE) who consistently report functional impairment in comparison to controls [5–7]. The primary goals of treatment are sustained seizure freedom with minimum treatment-associated side-effects.

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Surgery for temporal lobe epilepsy in the elderly: improving quality of life despite cognitive impairment

Epilepsy is one of the most common neurological diseases, leading to premature death, cognitive impairment and diminished quality of life[1,2]. About one third of all epilepsies are drug-resistant and surgery for drug-resistant focal epilepsy is safe and effective treatment option with proven better results than medical treatment in cases with temporal lobe epilepsy[3,4].

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Importance of prompt diagnosis in pediatric epilepsy outcomes

Epilepsy is one of the most common neurological disorders affecting individuals worldwide [1]. Every year in Canada, 15,500 individuals are diagnosed with epilepsy [2]. The incidence of pediatric epilepsy in Canada is 41 per 100,000 children per year [3]. The diagnosis of childhood epilepsy can involve a lengthy waiting period between the first seizure and the first appointment with a medical professional (Brodie et al., 2012; Dragoumi et al., 2013). In emergency situations, patients can receive medical assessment by a ...

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The Development of a Smartphone Application to Help Manage Epilepsy in Resource-Limited Settings

Epilepsy is a common and relatively treatable condition; about two thirds of people with it can have their seizures reduced using available medicines which are usually not excessively expensive[1]. When seizures continue, particularly if they are convulsive, people with epilepsy (PWE) are exposed to significant risks. They are up to six times more likely to die prematurely than people without epilepsy[2,3]. Burns and fractures are much more common. And very importantly, they, and their families, are subject to significant social ...

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Absence seizure provocation during routine EEG: Does position of the child during hyperventilation affect the diagnostic yield?

Absence seizures are generalized epileptic seizures with a characteristic ictal electroencephalographic (EEG) pattern of generalized, 3 Hertz (Hz) spike-and wave discharges.1,2 The mean duration of an absence seizure is 4-20 seconds (range 3-40 seconds), and it begins and ends abruptly, manifesting as cessation of activity, unresponsiveness, and staring with/without eye flutter, lip-smacking or head dropping.

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Driving rate and road traffic accidents in drivers with functional (psychogenic nonepileptic) seizures

Functional seizures (FS) or psychogenic nonepileptic seizures (PNES) are characterized by paroxysmal and self-limited events that semiologically may resemble epileptic seizures, but without ictal epileptiform discharges; they are thought to have a psychological origin [1]. Many patients with FS (PNES) report loss of responsiveness with their events [2,3] and loss of responsiveness in FS (PNES) is significantly associated with seizure-related injuries [4]. In addition, drivers with neurological conditions or psychiatric disorders have been found to be more likely to cause ...

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Towards a pragmatic epilepsy classification: future considerations

We read with interest the commentary “Could the 2017 ILAE and four-dimensional epilepsy classifications be merged to a new ‘Integrated Epilepsy Classification’?” [1]. This piece co-authored by a large group of top epilepsy luminaries discusses using comorbidity, epilepsy type, epilepsy syndrome, seizure type, and aetiologies in creating an Integrated Epilepsy Classification system (IEC). It considers merging the 2017 International League of Epilepsy (ILAE) classification and the four-dimensional epilepsy classification updated in 2019 [1].

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