Validation of items on the NDDIE and PHQ-9 associated with suicidal ideation during suicidality screening in patients with epilepsy

Suicide is an important cause of death, making it a global social and health issue [1]. Around 800,000 people worldwide die by suicide per year, with this number increasing in South Korea and worldwide [1–3]. Suicide is also a principal cause of death in patients with epilepsy (PWE) [4, 5], with more suicide attempts and significantly higher mortality among PWE than in the general population. The suicide risk in PWE is associated with psychiatric comorbidities, as well as with younger ...

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The impact of childhood epilepsy on academic performance: a population-based matched cohort study

Epilepsy is a neurological disorder characterised by spontaneous and recurrent seizures. Although epilepsy has a wide range of aetiologies, the cause of seizures often remains unidentified [1]. Epilepsy is a leading cause of disability in young people, and the global prevalence among young people aged ≤19 years is estimated to be almost 1% (i.e., approximately 23 million young people worldwide) [2]. In Australia, about 1 in 200 children are living with epilepsy, with an estimated total direct and indirect annual ...

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Impact of number of anti-seizure medications on long-term health-related quality of life in children with epilepsy: a prospective cohort study

Epilepsy is a chronic neurological disease characterized by recurrent seizures that places a major burden on patients, their caregivers, the healthcare system, and society [1, 2]. Health-related quality of life (HRQL) is a multidimensional concept aiming to quantify physical, social, cognitive, behavioral, and psychological well-being of patients [3]. Researchers and clinicians have implemented a broad use of HRQL measures to evaluate the impact of diagnoses and therapy in children with chronic health conditions such as epilepsy [4].

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Core outcome set development for childhood epilepsy treated with ketogenic diet therapy: results of a scoping review and parent interviews

Epilepsy is a neurological disorder characterised by recurrent epileptic seizures. Up to 67% of children with epilepsy will have seizures controlled by anti-seizure medication or enter spontaneous remission. [1] Early control of seizures is associated with better developmental outcome [2], but many childhood epilepsies have a poor prognosis for seizure control. [3] Up to 35% of children will be refractory to standard anti-seizure medication [4] and continue to experience regular debilitating seizures.

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Neuropathology findings in KCNQ2 neonatal epileptic encephalopathy.

KCNQ2-epileptic encephalopathy (EE) usually manifests as a neonatal epilepsy syndrome characterized by tonic episodes, focal clonic activity, and autonomic changes [1]. Early EEG recordings typically show a burst-suppression pattern or a multifocal epileptiform activity [1]. Basal ganglia hyperintensities may be found at early brain MRI. A large majority of children with KCNQ2-EE become seizure-free before three years of age, but developmental impairment remains severe in two thirds of the patients.

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Psychogenic non-epileptic seizures arising almost exclusively from sleep

Seizures occurring predominantly from sleep provide good evidence for epilepsy, and a nocturnal seizure is duly amongst the major diagnostic criteria for the “first epileptic seizure” [1]. On the other hand, the dictum that psychogenic non-epileptic seizures (PNES) do not occur from sleep is widely accepted by clinical epileptologists and neuropsychiatrists with interest in PNES. Although patients with PNES may often report events arising from sleep [2], video-EEG studies have demonstrated that PNES actually occur during “pseudo-sleep”, i.e., when patients ...

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War in Ukraine and seizure: Correspondence

Dear Editor, we read the publication on “Should a scientific epilepsy journal feature a picture highlighting the war in Ukraine on its front cover [1]. The Editor stated, “The main reason I believe it is appropriate for Seizure to feature an image of Ukraine on its front cover is that our concern about the suffering in Ukraine is likely to sensitize us to some more complex emotions, such as shame about feeling less concern about the suffering of people in ...

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