Seizure

: Specific antiseizure medications (ASM) would improve the outcome in post-stroke epilepsy (PSE). The aim of this multicenter observational study was to compare different antiseizure monotherapies in PSE.

Whether SARS-CoV-2 infects, and how it affects, the central nervous system (CNS) in the acute phase of disease has been an issue of research and discussion during the Covid-19 pandemic. The virus does not appear to be highly neurotropic or neuroinvasive, although rare cases of SARS-CoV-2 related encephalitis have been described [1].

Non-epileptic seizures (NES) are events that resemble the appearance of epileptic seizures but are not associated with electrophysiological changes characteristic of epilepsy [1]. NES come under the umbrella term of Somatic Symptom and Related Disorders and are classified as Conversion Disorder (Functional Neurological Symptom Disorder) in the DSM-5, or Dissociative neurological symptom disorder as classified in the ICD-11 [2,3].

Syntaxin-binding protein 1 (STXBP1) is predominantly expressed in the brain and plays an important role in synaptic vesicle docking and fusion [1]. STXBP1 mutations were first reported in patients with Ohtahara syndrome (OS) [2]. Subsequently, various phenotypes of these mutations have been identified, including West syndrome (WS), unclassified early-onset epileptic encephalopathy, and intellectual disability without epilepsy [3].

Juvenile myoclonic epilepsy (JME) is one of the most common idiopathic generalized epilepsies (IGE), accounting for up to 10% of all epilepsies. It is characterized by the main features of myoclonus with generalized spike-and-wave (GSWDs) and polyspike-and-waves on EEG [1]. The seizures in JME often start and terminate through a sudden transition and the pathophysiology of JME remains unknown. In general, JME is considered involving wide brain networks including cortical and subcortical networks, especially the fronto-thalamic networks [2].

: To evaluate the effectiveness and tolerability of perampanel (PER) in real-world settings in patients between 1 month and 18 years of age with drug resistant epilepsy (DRE) waiting for epilepsy surgery.

Obstructive sleep apnea (OSA) is a breathing disorder characterized by intermittent narrowing or collapse of the upper airway during sleep[1]. The prevalence estimates of OSA in patients with epilepsy vary widely, ranging from 10% to 88.9%[2–3]. The risk factors for OSA in patients with characteristics of epilepsy have not been identified conclusively. Data on the association between risk of OSA and disease characteristics and AED use in patients with epilepsy with epilepsy are very limited. A study from the Cleveland ...

Kikuchi and colleagues must be commended for having investigated the temporal trends in prescribed anti-seizure medicines (ASMs) in Japanese women. [1] Indeed, ASMs’ teratogenicity has been by passed for too long: while first reports of valproate teratogenicity having been published in 1982, risk immunization measures were only issued in the mid 2010’s in Europe [2]. However, we are afraid that Kikuchi and colleagues’ report similarly illustrated how concerns for ASMs’ teratogenicity are not adequate in Japan yet.

Spontaneous intracerebral hemorrhage (sICH) is a stroke subtype associated with poor prognosis and high mortality. Seizure is a significant complication of ICH, with incidences ranging from 1.7% to 31% [1, 10, 40]. Regardless of the time from onset to ICH, seizures occurring after ICH and related to the occurrence of ICH are called post-ICH seizures. Post-ICH seizures are a combination of early-onset seizures(those occurring within 1–2 weeks of hemorrhage) and late-onset seizures (those occurring thereafter) [20, 29, 31].

Epilepsy is one of the most prevalent neurological disorders characterized not only by recurrent unprovoked seizures,[1] but also by frequent somatic and psychiatric co-morbidities.[2–6] Consequently, epilepsy has major socioeconomic consequences for patients, families, and society[7,8] in addition to a significant loss of disability-adjusted life-years (DALYs) and a reduced life expectancy.[9–13] In a systematic analysis of loss of DALYs, epilepsy ranked fifth among neurological disorders.[9] The Global Burden of Diseases (GBD) Study estimated global, regional, and country-specific prevalence from 317 studies ...