Anticonvulsant Effects of Sertraline: A Case Report

In people with epilepsy, depressive disorders are frequent comorbidities, constituting a challenge to complex treatment strategies. Administering antidepressants to such individuals is controversial because multiple studies and case reports indicate pro-convulsant effects for tricyclic antidepressants (TCAs) and in some cases for serotonin selective reuptake inhibitors (SSRIs) as well.[1] For this reason, TCAs are contraindicated in depressed people with epilepsy while SSRIs are often used in this population even though their possible pro-convulsant effects are variable.[2] We report the case of ...

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Psychiatric Co-Morbidities and Factors Associated with Psychogenic Non-epileptic Seizures: A Case-control study

Psychogenic nonepileptic seizures (PNES) are paroxysmal subjective or objective clinical manifestations resembling seizures that do not arise from epileptiform cortical discharges. These are now considered to be ‘experiential and behavioural responses’ to internal or external stimuli [1,2]. An international consensus clinical practice statement issued in 2011 ranked PNES among the top three neuropsychiatric problems, along with anxiety/ depression and psychosis [3]. It is now considered to be a biopsychosocial disorder with multifactorial aetiology [4,5].

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Predictors of successful Ramadan fasting in Muslim patients with epilepsy: A prospective study

Ramadan is the name of a month in the Muslim lunar calendar. Ramadan fasting is a basic principle of Islam that involves fasting from dawn to sunset for one lunar month. During Ramadan, healthy adult Muslims are allowed to eat and drink only between sunset and dawn. Fasting is not obligatory for prepubertal children, menstruating women and individuals with mental illness.

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Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus

Status epilepticus (SE) is one of the most common life-threatening neurological emergencies in children. The estimated incidence of convulsive SE in children is 10-38/100 000 every year, and mortality is currently between 0% and 7.5% [1–4]. The paediatric Status Epilepticus Research Group (pSERG) in the United States has reported an association between treatment delays and unfavourable short-term outcomes in children with refractory SE [2,4]. Age at onset and duration of SE were independently associated with worse neurocognitive outcomes in a ...

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Association of common genetic variants with vitamin D status in Malaysian children with epilepsy

Epilepsy is the most common paediatric neurological disorder, with an average annual rate of 5–7 new cases per 10,000 children [1]. Treatment of epilepsy involves long-term therapy of antiseizure medication, which expose patients to potentially undesirable metabolic bone health adverse effects such as vitamin D deficiency [2]. Vitamin D is an important determinant of growth and body development during childhood and adolescence [3–5]. Paediatric studies have shown that long-term antiseizure medication therapy is associated with vitamin D deficiency resulting in ...

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Trends in hospitalization and readmission for pediatric epilepsy and underutilization of epilepsy surgery in the United States

Epilepsy is one of the most common neurologic disorders, affecting 0.5%–1.0% of the general population [1,2]. Approximately 35% of patients with epilepsy have medically refractory epilepsy and epilepsy surgery may be the only curative option [3,4]. Despite adequate trials of antiepileptic drugs, the persistence of seizures in refractory cases accounts for more than 75% of the cost of epilepsy care in the United States [5,6]. Although epilepsy surgery for well-selected candidates with medically refractory epilepsy could achieve seizure freedom in ...

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Clinical characteristics and fetal outcomes in women with epilepsy with planned and unplanned pregnancy: a retrospective study

Epilepsy is a common neurological disease that affects approximately 12.5 million women of childbearing age worldwide [1]. Compared with healthy individuals, women with epilepsy (WWE) often have increased risk of pregnancy complications, for example, gestational hypertension, pre ­ eclampsia, post-partum hemorrhage, antepartum hemorrhage, placental abruption premature rupture of membranes, preterm labor, and cesarean section [2–6]. Furthermore, infants of WWE who take antiepileptic drugs (AEDs) are at an additional risk of major congenital malformations (MCMs) [7,8], neurodevelopmental delays [9], and low birth weights ...

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Report on a psychoeducational intervention for psychogenic non-epileptic seizures in Argentina

Psychogenic non-epileptic seizures (PNES) are sudden and involuntary episodic events, which cause an alteration in normal functioning and a reduction in self-control; they are associated with motor, sensory, mental or autonomic manifestations [1,2]. Although they are similar to epileptic seizures, they are not caused by epileptogenic activity in the brain. PNES are categorized as functional neurological disorders (FND)/conversion disorders within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) [3].

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