High-dose prednisone therapy for infantile spasms and late-onset epileptic spasms in China: The addition of topiramate provides no benefit

Infantile spasms (IS) has been described as a challenging epilepsy syndrome because its drug resistance and poor prognosis, which have given rise to a large burden on society and patients’ families. IS typically have an onset between 3 and 12 months of age with a peak incidence around 6-7 months [1].However, the patients were divided into three groups by age at onset of spasms [2]: early onset ( less than 3 months), classic onset (3 months and up to 12 ...

Seguir leyendo →
0

Impact of Knowledge, Attitudes, and Sociocultural Factors on School Enrollment of Children With Epilepsy in Gabon

Epilepsy is a common disorder that occurs worldwide in all age groups and without distinction of gender. There are many superstitious beliefs in African counties about etiology of epilepsy [1–5]. In some of these countries, traditional healers, teachers, and students have linked epilepsy to spiritual attacks and witchcraft. Furthermore, epilepsy is widely believed to be transmissible by direct or indirect contact with body fluids of patients such as saliva and urine [6,7]. Therefore, children with epilepsy (CWE) are often stigmatized, ...

Seguir leyendo →
0

Jeavons syndrome in a family with GLUT1-Deficiency Syndrome

Glucose transporter-1 (GLUT1)/SLC2A1 is expressed at the highest levels in brain capillaries, astroglia, and erythrocytes. GLUT1-deficiency syndrome is a neurological disorder resulting primarily from aberrant glucose transport into the brain. Clinically, it is classified as GLUT1-deficiency syndrome with epilepsy and without epilepsy. The phenotypic spectrum of GLUT1- deficiency syndrome expanded over last two decades, encompassing a varying combination of epilepsies (absence, atypical absence, myoclonic, myoclonic-astatic, refractory generalized epilepsy, intractable infantile epilepsy etc.), movement disorders (paroxysmal exercise-induced dyskinesia, ataxia, etc.), and ...

Seguir leyendo →
0

Study of the hippocampal internal architecture in temporal lobe epilepsy using 7 T and 3 T MRI

Magnetic resonance imaging (MRI) is a well-recognized diagnostic tool in most brain disorders. Today, high-strength magnetic field (3 Tesla) MRI are standard. Though 7 T MRI are not currently widely used yet, it becomes more and more available for clinical and neuroscientific researchers. However, the higher spatial resolutions that are possible at ultra high field imaging increase scan time as a result, which can result in patient discomfort. The main complaint at ultra high field followed by nausea, light flashes, metallic taste ...

Seguir leyendo →
0

Automated Spectrographic Seizure Detection Using Convolutional Neural Networks

Non-convulsive seizures (NCS) are common in critically ill patients (8-50%) [1–6], and if untreated, are associated with high mortality (17-51%) [6–8]. Furthermore, effective treatment must be timely, as delayed treatment can lead to long term neurologic disability [9–11]. Many intensive care units (ICU) now perform continuous EEGs (cEEG) to monitor for NCS. However, although continuously recorded, cEEGs are rarely continuously monitored. Even in large academic medical centers, cEEGs are typically reviewed 2-3 times daily by a neurophysiologist.

Seguir leyendo →
0

Burden in caregivers of adults with epilepsy in Asian families

Epilepsy is an unpredictable, intrusive illness that impacts not only the patients but also those who care for them [1]. People with epilepsy (PWE) consistently report lower quality of life, higher levels of depression andanxiety [1]. Epilepsy could cause psychosocial distress, disrupt family routines and reorientthe interests and activities of family members.

Seguir leyendo →
0

Clinical Outcomes of Closed-Loop Vagal Nerve Stimulation in Patients with Refractory Epilepsy

Epilepsy is a group of neurological disorders characterized by recurrent epileptic seizures with a prevalence rate of 0.5%-1% among children [1]. Most patients are successfully treated with anti-epileptic drugs, but about a third suffer from treatment-resistant epilepsy (TRE) [2]. Vagal nerve stimulation (VNS), approved by U.S Food and Drug Administration (USFDA) in 1997, is a safe and efficacious treatment for TRE, consisting of an implanted pacemaker-like generator and nerve stimulation electrodes, that delivers intermittent stimulation to the patient’s left vagus ...

Seguir leyendo →
0

CT perfusion and EEG patterns in patients with acute isolated aphasia in seizure-related stroke mimics

Stroke mimic (SM) is a set of conditions with clinical presentation similar to that of an acute ischemic stroke (AIS), albeit not caused by an ischemic event [1]. From 1% to 41% of patients presenting stroke-like symptoms at admission to the Emergency Department are actually SM [2]. The most common SM etiologies are seizure (38%), migraine with aura (37%), and conversion disorder (21%) [3]. Other conditions of SM are metabolic, infectious, neurodegenerative disorder, peripheral neuropathy and syncope [3].

Seguir leyendo →
0

Risks and management of antiepileptic drug induced skin reactions in the adult out-patient setting

A history of allergic drug reactions often limits the choice of medical treatment. These are reported in 10% of community case notes and for up to 35% of patients attending a US teaching hospital [1]. Current assessment of drug hypersensitivity in the UK relies on self-reporting. This is often misleading. In over 40% of cases, penicillin intolerance is incorrectly labeled as ‘allergy’ [2].

Seguir leyendo →
0
Página 4 de 77 «...23456...»