Ictal biting injuries in the epilepsy monitoring unit, a cohort study of incidence and semiological significance

Oral lacerations are widely recognized as potential complications of seizures. These are mostly minor injuries requiring some degree of pain control, but occasionally require repair or result in more serious complications [1,2]. Diagnostic value of ictal tongue biting has been extensively evaluated, demonstrating good positive predictive value of lateralized tongue-biting for epileptic seizure versus paroxysmal non-epileptic seizures [3,4,5].

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Seizure Detection Devices for use in Antiseizure Medication Clinical Trials: A Systematic Review

The need to address key limitations in validation studies is highlighted in order to support future assessments of SDD fitness for ASM clinical trial use. In tandem, a stepwise framework to streamline device testing is put forth. These suggestions provide a starting point for establishing SDD reporting requirements before device integration into ASM clinical trials.

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The clinical characteristics and related factors of tremor in patients with epilepsy

Tremor is defined as an involuntary, rhythmical, oscillatory movement of a body part produced by either synchronous or alternating contractions of antagonist muscles [1]. As one of the most common neurological symptoms, tremor was frequently seen in patients with epilepsy (PWE). According to the Epilepsy Comorbidities and Health (EPIC) Survey, 9.3% of the respondents with epilepsy reported perceived movement disorder/tremor, more than twice as prevalent as those without epilepsy [2].

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Disappearance of symptomatic generalized 3-Hz discharges after focal surgery in a patientwithtuberous sclerosis

Patients with tuberous sclerosis complex (TSC) usually present with epileptic spams and/or focal seizures and can be good candidates for epilepsy surgery [1]. Typical absence seizures (TAS) are generalized with sudden onset and termination, lasting a few seconds, and electrographically defined by a unique EEG signature: diffuse, regular, >2.5-Hz spike-and-wave discharges (SWD). Some data suggest a focal origin for thesegeneralized SWD, in particular, from themesial or polar aspects of the frontal lobe.

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Epileptic Seizure Detection Using Cross-Bispectrum of Electroencephalogram Signal

Epilepsy is a common neurological disorder associated with recurrent and sudden excessive electrical discharges in a group of brain neurons that can disrupt the patient’s behavior and function temporarily [1]. Common treatments for epilepsy (medication and surgery), that often come with several side effects, are not able to control seizures in almost 25% of the patients. These patients must live with seizures that can happen anytime and anywhere [2]. Since epileptic seizures are related to the electrical activity of the ...

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Retinoencephalopathy with occipital lobe epilepsy in an OPA-1 mutation carrier

A 26-year old warehouse employee first presented with subacute, holocephalic headache of moderate intensity, dizziness, and a “red, flickering pixel” in his right visual field, followed by two bilateral tonic-clonic seizures a few days later. The initial clinical examination, EEG, brain MRI and blood work were unremarkable except for rhabdomyolysis (CK ˜10.000 U/l; upper limit of normal is 190 U/l), which was considered as complication associated with tonic-clonic seizures. During the following months, the patient suffered from intermittend fluctuating right ...

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CADASIL presenting with focal and generalised epilepsy due to a novel NOTCH3 mutation

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant small vessel disease caused by mutations of the NOTCH3 gene [1]. Clinical manifestations of CADASIL include headaches, recurrent ischaemic strokes, and progressive cognitive decline. Seizures are an uncommon symptom and were previously reported as occurring late in the disease course, after onset of stroke [1]. We report a CADASIL family with epilepsy as an early symptom due to a novel NOTCH3 mutation.

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Factors associated with seizure-related motor vehicle accidents among patients with epilepsy in West China

Epilepsy is characterized by unpredictable seizures [1]. Loss of consciousness during seizures may influence the driving ability of patients with epilepsy (PWE) and result in motor vehicle accidents (MVA) [2]. In China, PWE have been forbidden from driving motor vehicles since 1988, according to the Regulations of the People’s Republic of China on Road Traffic [3]. Provisions on the Application for and Use of Driving Licenses, which took effect in 2004, ban all PWE from obtaining a driver’s license [4].

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Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy:identification of a new KCND3 phenotype and novel genes causing Dravet syndrome

Epilepsy is one of the most common pediatric neurologic disorders, with an incidence of 7/10,000 per year before the age of two (1). The etiology of epilepsy is diverse and complex, and genetic factors play an important role. Many genes have been associated with epilepsy, such as ion channel genes, genes related to transmitter trafficking, and genes associated with cell connections (2). Clarifying the genetic background of epilepsy is very important for its diagnosis, treatment, and prognosis. Importantly, it also ...

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