DC shifts, High Frequency Oscillations, Ripples and Fast Ripples in Relation to the Seizure Onset Zone

The success of epilepsy surgery relies on the accurate localization and complete resection or disconnection of the epileptogenic zone (EZ) from surrounding brain tissue. The epileptogenic zone is defined as the minimum amount of cortex that must be resected to produce seizure freedom and is consequently an area that can only be identified retrospectively based on epilepsy surgery outcome [1]. In contrast, the seizure onset zone (SOZ) is defined as the area of cortex where the seizure is generated and ...

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Effect of brivaracetam on the anger levels of epilepsy patients. A prospective open-labelled controlled study

Anger and irritability are features of the aggressive behaviour described to be present in up to 7% of epilepsy patients [1]. History of psychiatric conditions, uncontrolled seizures and static encephalopathies have been the risk factors most commonly associated with aggressive behaviour [1]. However, medical treatment often results in behavioural changes in patients and some antiepileptic drugs (AEDs) have demonstrated a high risk of developing psychiatric adverse events [2]. The majority of AEDs may induce at some point positive or negative ...

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Vitamin D Abnormalities and Bone Turn over Analysis In Children With Epilepsy In The Western Cape of South Africa

An estimated 50 million people worldwide have epilepsy, 85% of whom reside in the low and low-middle income countries (LMICs). [1] In sub-Saharan Africa only 36% of children with epilepsy have access to antiseizure medications (ASMs) and 95% of this group are managed with phenobarbital. [2] One of the chronic side effects of ASMs are abnormalities in bone metabolism. [3,4]

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The Landscape of Early Infantile Epileptic Encephalopathy in a Consanguineous Population

Epileptic encephalopathies (EE), are disorders of the developing brain characterized by intractable seizures and electroencephalogram (EEG) abnormalities, that typically result in cognitive and motor delay, regression, and sometimes death. [1,2] Forty percent of seizures in children aged three years or less can be classified as EE. [3] Early infantile epileptic encephalopathy (EIEE) have their onset during infancy and are highly variable in etiology and natural history. While seizure is the core symptom for all EIEE syndromes often accompanied by progressive ...

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Prevalence of sleep disturbances in people with epilepsy and the impact on quality of life: A survey in secondary care

Subjective sleep disturbances are more often seen in people with epilepsy (PWE) than in healthy controls. Questionnaire-based studies in specialized epilepsy clinics suggest that more than a third of adults with refractory epilepsy have a sleep disturbance, twice as often as in controls1,2. In children with epilepsy, the prevalence of sleep disturbances is even higher, being ten times that of classmates of the same age without epilepsy3. In the general community, the prevalence of obstructive sleep apnea syndrome (OSAS) is ...

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Impact of antiepileptic drugs for seizure prophylaxis on short and long-term functional outcomes in patients with acute intracerebral hemorrhage: A meta-analysis and systematic review

Intracranial hemorrhage (ICH) is one of the most devastating forms of stroke with a reported mortality rate of up to 50% in the literature. [1] One complication is the development of seizures that occurs in 2%-40% of patients post-ICH. The significant variation in incidence is related to the type and duration of monitoring, length of follow-up, and patient characteristics including hemorrhage volume, hemorrhage location, and cortical involvement [2–12].

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A Very Rare Form of Autosomal Dominant Progressive Myoclonus Epilepsy Caused by a Novel Variant in the PRICKLE1 Gene

Progressive myoclonus epilepsy (PME) comprises a group of rare heterogeneous genetic disorders that are generally manifested as a combination of myoclonic and tonic-clonic seizures with cognitive impairment, ataxia and other cerebellar signs, and other neurologic deficits. They are often encompassed under the broader term “catastrophic epilepsies”, which are invariably associated with significant neurological morbidity and often early mortality. This group also include epileptic encephalopathies [1].

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