Automatic assessment of the myoclonus severity from videos recorded according to standardized Unified Myoclonus Rating Scale protocol and using human pose and body movement analysis

Many neurological diseases such as epilepsy cause abnormal body posture or abnormal movement of body parts. These abnormal involuntary movements, such as muscle twitches, myoclonic jerks or other motor manifestations during epileptic seizures, provide important information that can be used to diagnose and assess disease severity and progression.

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Exploring epilepsy attendance at the emergency department and interventions which may reduce unnecessary attendances: a scoping review

Epilepsy is a common neurological conditions [1] with a prevalence of 4-10 cases per 1000 persons and an average yearly incidence of 80/100,000 persons [2,3]. Anti-seizure medications (ASMs) are the mainstay epilepsy treatment and there is evidence that they stop seizure in about 70% of people [4]. Across the globe, the World Health Organisation estimates that epilepsy causes 6.4million disability adjusted life years and 1.32 million years of life lost [1]. For people living with epilepsy, it can have significant ...

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Plasma-lactate levels in simulated seizures – an observational study

Differentiating between epileptic seizures, convulsive syncope or non-epileptic seizures is a common diagnostic challenge in the acute setting.Lactate levels has previously been proposed as a tool to aid in differentiating between epileptic and non-epileptic seizures, with lower levels of lactate suggesting a non-epileptic origin.The aim of this study was to investigate levels of lactate in non-epileptic seizures.

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DETERMINING THE QUALITY OF LIFE OF CHILDREN LIVING WITH EPILEPSY IN KENYA – A CROSS-SECTIONAL STUDY USING THE CHEQOL-25 TOOL

Epilepsy in childhood has far reaching effects on development: it is a major contributor of childhood impairment and disability and can negatively impact on a child’s physical, social and psychological abilities, all of which limit life opportunities, life span and overall well-being (1,2). As children grow older, these effects become more manifest as cognitive ability and life experience increases, and thus children with epilepsy (CWE) are more able to express how they are affected by the disorder.

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Somatostatin receptor expression and mTOR pathway activation in glioneuronal tumours of childhood

Glioneuronal tumours, mainly ganglioglioma (GG) and dysembryoplastic neuroepithelial tumours (DNETs), are the most frequent long-term epilepsy associated tumours (LEATs) of childhood (1). Survival rates are excellent, but most of these tumours give rise to epilepsy with focal seizures with impairment of awareness (2–6). Medication with today’s antiepileptic drugs (AEDs) may provide temporary relief, but most patients will inevitably need neurosurgery with gross total resection (GTR), which provides a high possibility of achieving long-term seizure freedom (4,7–9).

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Valproic acid prescription trends among females of childbearing age in Estonia: A 14-year nationwide prescription database study

Valproic acid (VPA), also known as valproate, is among the most frequently prescribed antiepileptic drugs (AEDs). A major safety issue with VPA is its teratogenicity. Data from several pregnancy registries have consistently shown that the offspring of mothers who use VPA during pregnancy are at greater risk of major congenital malformations [1,2]. Reports have described impaired intellectual and behavioural development in children exposed to VPA in utero [3]. In response to these data, the European Medicines Agency (EMA) strengthened its ...

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Posterior reversible encephalopathy syndrome in preeclampsia and eclampsia: The role of hypomagnesemia

Posterior reversible encephalopathy syndrome (PRES), also known as reversible posterior leukoencephalopathy syndrome (RPLS), is a special type of cerebrovascular disease defined by its clinical and imaging manifestations [1]. The onset of PRES typically occurs acutely or subacutely and involves a variety of nonspecific symptoms, including headaches, visual changes, seizures, consciousness impairment, mental disorders, focal neurologic deficits, nausea, and vomiting [2,3]. MRI is the gold standard for the diagnosis and evaluation of PRES [4], and the imaging features of this condition ...

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Neurocysticercosis in People with Epilepsy in Sub-Saharan Africa: A Systematic Review and Meta-analysis of the Prevalence and Strength of Association

Epilepsy is one of the most common neurological disorders throughout the world [1]. The devastating impact of epilepsy on people with epilepsy and the society at large cannot be overemphasized. Sub-Saharan Africa (SSA) is home to a large proportion of people with epilepsy. The causes of epilepsy in SSA vary with infections of the central nervous system at the forefront of the etiologies [1,2].

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Evaluation of Olfactory and Gustatory Changes in Patients with Mesial Temporal Lobe Epilepsy

The relationship between olfaction, which is one of the chemosenses, and epilepsy has long been of interest to physicians. In the 19th century, olfactory dysfunction was observed in patients with temporal lobe epilepsy. Temporal lobe structures were therefore thought to have a role in olfactory function 1. Various studies since have revealed that the temporal lobe plays an important role in the perception of odors. In particular, the entorhinal cortex, the piriform cortex, and the amygdala are closely related to ...

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