Response to Zhang et al.: Levetiracetam vs. brivaracetam for adults with refractory focal seizures: A meta-analysis and indirect comparison

We read with interest the meta-analysis and indirect comparison of levetiracetam and brivaracetam recently presented by Zhang et al. (Seizure 2016;39:28–33) [1]. We would like to raise two points in response. Firstly, some methodological elements common to indirect comparisons have not been addressed in the published work. Secondly, the use of network meta-analyses of clinical trials to produce valid evidence of the comparative efficacy and safety of antiepileptic drugs (AEDs) has previously been called into question, which was not discussed ...

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The burden of headache in people with epilepsy

Epilepsy is defined as a brain disorder characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition [1]. Approximately 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally [2]. One of the most useful methods to measure overall burden of a disease is the Disability-adjusted life years (DALYs); these are higher for epilepsy than for Alzheimer’s disease, Parkinson’s disease and multiple sclerosis ...

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