Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death in patients with medically refractory epilepsy and a major public health problem. Increasing evidence implicates seizure-induced respiratory depression in the chain of events leading to SUDEP[1]. In the landmark MORTEMUS study of patients who died of SUDEP while undergoing video-EEG monitoring, all recorded deaths occurred shortly after a generalized convulsive seizure (GCS)[2]. In all 9 patients in whom heart and respiratory rate could be measured, terminal apnea preceded ...
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