Abstract
Objective
Lennox–Gastaut syndrome (LGS) is a childhood onset developmental and epileptic encephalopathy characterized by multiple seizure types that are often refractory to traditional antiseizure medications. Neuromodulation therapies including vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS) have emerged as potential treatment options, but their comparative efficacy remains unclear.
Methods
We conducted a systematic review and meta-analysis of studies reporting outcomes of neuromodulation therapies in patients with LGS. A comprehensive search of electronic databases was performed through July 26, 2024. ...
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