Epilepsy is associated with significant morbidity worldwide. The advent of anti-seizure medications (ASMs) during the 20th century has vastly improved seizure control. However, these medications are not without risk including potential cardiac consequences. [1] Certain ASMs have been suggested to have a direct cardiotoxic effect including increased atherogenesis through influence on lipid profile and an inflammatory milieu. [2] Additionally, a common mechanism of action of ASMs involves inhibition of voltage-gated sodium ion channels.
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