The possibility of adverse effect of Kv7-channel opener retigabine on memory processes in rats

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Ewa Zwierzyńska, Agata Krupa-Burtnik, Bogusława Pietrzak

Objective
Retigabine is a novel antiepileptic drug with a unique and complex mechanism of action which allows its use in many diseases associated with impaired neuronal activity. This study sought to examine the impact of retigabine on two types of memory in rats.
Methods
Adult male Wistar rats were ...

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Perampanel with concomitant levetiracetam and topiramate: Post hoc analysis of adverse events related to hostility and aggression

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Steve Chung, Betsy Williams, Cindy Dobrinsky, Anna Patten, Haichen Yang, Antonio Laurenza
In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1–3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy ...

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The psychological costs of comparisons: Parents’ social comparison moderates the links between family management of epilepsy and children’s outcomes

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Teresa P. Mendes, Carla A. Crespo, Joan K. Austin
Parents play a key role in how children deal with epilepsy. When diagnosed with health conditions, people seek comparison information from fellow patients and families, and this information has consequences for how they evaluate their situation. This study examined the moderating role of parents’ social comparison orientation ...

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Unraveling complex relationships among dysphoric disorder, localization-related epilepsy, and mood disorders

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Tetsufumi Suda, Yasutaka Tatsuzawa, Taichi Mogi, Aihide Yoshino

Background
Dysphoric disorder (DD), characterized by intermittent pleomorphic symptoms, has been believed to be specific to epilepsy. However, our previous study revealed that DD in patients with localization-related epilepsy was associated with a lifetime diagnosis of mood disorders. The present study was conducted to estimate the prevalence ...

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Provision of sudden unexpected death in epilepsy (SUDEP) information among Malaysian parents of children with epilepsy

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Choong Yi Fong, Wei Kang Lim, Ann Nie Kong, Pei Lin Lua, Lai Choo Ong
Sudden unexpected death in epilepsy (SUDEP) is an important cause of mortality in epilepsy. To date, there is only one published UK study evaluating information provision of SUDEP among parents of children with epilepsy (CWE), and there ...

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Clinical utility of serum lactate levels for differential diagnosis of generalized tonic–clonic seizures from psychogenic nonepileptic seizures and syncope

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Ebru Apaydın Doğan, Ali Ünal, Aslıhan Ünal, Çağla Erdoğan

Background
The differential diagnosis of generalized tonic–clonic seizures (GTCS), psychogenic nonepileptic seizures (PNES), and syncope constitutes a major challenge. Misdiagnosis rates up to 20 to 30% are reported in the literature.
Purpose
To assess the clinical utility of serum lactate levels for differentiation of ...

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An acidosis-sparing ketogenic (ASK) diet to improve efficacy and reduce adverse effects in the treatment of refractory epilepsy

Publication date: September 2017Source:Epilepsy & Behavior, Volume 74
Author(s): Alan W.C. Yuen, Isabel A. Walcutt, Josemir W. Sander
Diets that increase production of ketone bodies to provide alternative fuel for the brain are evolving from the classic ketogenic diet for epilepsy devised nearly a century ago. The classic ketogenic diet and its more recent variants all appear to have similar efficacy with approximately 50% of ...

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Neurobehavioral consequences of continuous spike and waves during slow sleep (CSWS) in a pediatric population: A pattern of developmental hindrance

Publication date: September 2017Source:Epilepsy & Behavior, Volume 74
Author(s): Valentina De Giorgis, Melissa Filippini, Joyce Ann Macasaet, Silvia Masnada, Pierangelo Veggiotti

Introduction
Continuous spike and waves during slow sleep (CSWS) is a typical EEG pattern defined as diffuse, bilateral and recently also unilateral or focal localization spike–wave occurring in slow sleep or non-rapid eye movement sleep. Literature results so far point out ...

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Topiramate-associated sexual dysfunction: A systematic review

Publication date: August 2017Source:Epilepsy & Behavior, Volume 73
Author(s): Louis Wei-Hsi Chen, Melody Yun-Si Chen, Kuo-Yen Chen, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin

Introduction
Sexual pharmacotoxicity renders patients with epilepsy at a risk for sexual dysfunction (SD). This study is aimed to analyze the relationship between sexual function and topiramate to avoid topiramate-associated SD.
Methods
A systematic review ...

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Impaired responsibility dimension of self-esteem of Brazilian adolescents with epilepsy

Publication date: August 2017Source:Epilepsy & Behavior, Volume 73
Author(s): Nathália F. Siqueira, Fernando L.B.B. Oliveira, Elisabete Abib Pedroso de Souza
This study aimed to compare the self-esteem of Brazilian adolescents with epilepsy and Brazilian adolescents without this condition and the correlations between self-esteem of these adolescents with depression and anxiety symptoms. Study participants were 101 adolescents of both sexes, aged 10–19years old, from elementary ...

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