Systematic review of unmet healthcare needs in patients with epilepsy

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Mayuri Mahendran, Kathy N. Speechley, Elysa Widjaja

Objective
Patients with epilepsy (PWE) are more likely to have unmet healthcare needs than the general population. This systematic review assessed the reasons for unmet needs in PWE.
Methods
Medline, Embase, PsycINFO, Cochrane, and Web of Science databases were searched using keywords relating to unmet healthcare needs, treatment ...

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Predictive coding: A contemporary view on the burden of normality and forced normalization in individuals undergoing epilepsy surgery

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Sumayya Mehmood, Craig Dale, Monica Parry, Carter Snead, Taufik A. Valiante
Following epilepsy surgery, a good psychosocial outcome is not necessarily contingent on a good seizure outcome. Increasingly, it is believed that “successful” surgery is a combination of both an acceptable and expected seizure status as well as the individual’s perception of ...

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“Atypical forms” of benign epilepsy with centrotemporal spikes (BECTS): How to diagnose and guide these children. A practical/scientific approach

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Pasquale Parisi, Maria Chiara Paolino, Umberto Raucci, Alessandro Ferretti, Maria Pia Villa, Dorothee Kasteleijn-Nolst Trenite
Benign epilepsy with centrotemporal spikes (BECTS) epilepsy, also known as rolandic epilepsy, is the most common childhood type of epilepsy. There is debate on its “benign” definition given the numerous literature data on its correlation ...

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Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Luciano R. Vilela, Isabel V. Lima, Érica B. Kunsch, Hyorrana Priscila P. Pinto, Aline S. de Miranda, Érica Leandro M. Vieira, Antônio Carlos P. de Oliveira, Marcio Flávio D. Moraes, Antônio L. Teixeira, Fabricio A. Moreira
Cannabidiol (CBD), the main nonpsychotomimetic compound ...

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Intranasal pitavastatin attenuates seizures in different experimental models of epilepsy in mice

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Muhammad Usama Ashhar, Mohd. Zubair Ahmad, Vikas Jain, Nidhi B. Agarwal, Farhan J. Ahmad, Gaurav K. Jain
This study was carried out to evaluate the effect of intranasal pitavastatin (PVS) on pentylenetetrazole (PTZ)-induced seizures, increasing current electroshock (ICES) seizures, and status epilepticus in mice. Intranasal PVS, 0.5 and 1.0mg/kg, ...

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Protective effect of naringin on pentylenetetrazole (PTZ)-induced kindling; possible mechanisms of antikindling, memory improvement, and neuroprotection

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Phani Kumar Kola, Annapurna Akula, Lakshmi Sudeepthi NissankaraRao, R. CH. Sekhara Reddy Danduga
The present study investigated the effects of Naringin on seizure severity, progress of kindling, memory impairment, oxidative stress, neurochemicals, and neural damage in Pentylenetetrazole (PTZ)-induced kindling. Alternate intra-peritoneal injections of PTZ induced kindling at 22 injections of PTZ. In comparison with ...

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The role of necroptosis in status epilepticus-induced brain injury in juvenile rats

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Qianyun Cai, Jing Gan, Rong Luo, Yi Qu, Shiping Li, Chaomin Wan, Dezhi Mu

Purpose
To study the role of necroptosis in status epilepticus (SE)-induced injury in the developing brain and the possible associations of necroptosis with epileptogenesis and cognitive dysfunction.
Methods
The lithium-pilocarpine epilepsy model was ...

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Epilepsy may cause increased pain sensitivity: Evidence from absence epileptic WAG/Rij rats

Publication date: October 2017Source:Epilepsy & Behavior, Volume 75
Author(s): Sibel K. Velioglu, Oznur Gedikli, Mehmet Yıldırım, Ahmet Ayar

Objective
The comorbidity of epilepsy and pain disorders as well as effectiveness of certain therapeutic approaches in both conditions attracted attention to epilepsy–pain interactions. This lead to the discovery of significantly shared pathophysiological mechanisms although many aspects remain largely unknown. To test the hypothesis that epilepsy ...

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