Counseling by epileptologists affects contraceptive choices of women with epilepsy

Publication date: December 2016Source:Epilepsy & Behavior, Volume 65
Author(s): Alyssa R. Espinera, Jay Gavvala, Irena Bellinski, Jeffrey Kennedy, Micheal P. Macken, Aditi Narechania, Jessica Templer, Stephen VanHaerents, Stephan U. Schuele, Elizabeth E. Gerard

Introduction
There are several important interactions between antiepileptic drugs (AEDs) and hormonal contraception that need to be carefully considered ...

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Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Francesco Brigo, Nicola Luigi Bragazzi, Susanna Bacigaluppi, Raffaele Nardone, Eugen Trinka

Background
Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE).We aimed to critically assess all the available data on efficacy and tolerability of ...

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Mortality in Dravet syndrome: A review

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Sharon Shmuely, Sanjay M. Sisodiya, W. Boudewijn Gunning, Josemir W. Sander, Roland D. Thijs

Introduction
Premature mortality is a major issue in Dravet syndrome (DS). To improve understanding of DS premature mortality, we conducted a comprehensive literature search with a particular emphasis on SUDEP.
Methods
We searched PubMed, Embase, ...

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Direct and indirect comparison meta-analysis of levetiracetam versus phenytoin or valproate for convulsive status epilepticus

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Francesco Brigo, Nicola Bragazzi, Raffaele Nardone, Eugen Trinka

Aim
The aim of this study was to conduct a meta-analysis of published studies to directly compare intravenous (IV) levetiracetam (LEV) with IV phenytoin (PHT) or IV valproate (VPA) as second-line treatment of status epilepticus (SE), to indirectly compare intravenous IV LEV with IV VPA ...

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Postictal alterations induced by intrahippocampal injection of pilocarpine in C57BL/6 mice

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Isabel Vieira de Assis Lima, Alline Cristina de Campos, Paula Maria Quaglio Bellozi, Juliana Guimaraes Doria, Fabiola Mara Ribeiro, Marcio Flavio Dutra Moraes, Antonio Carlos Pinheiro de Oliveira
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults. The pilocarpine (PILO) experimental model ...

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Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the DBA/1 mouse model of SUDEP

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Carl L. Faingold, Marcus Randall, Chang Zeng, Shifang Peng, Xiaoyan Long, Hua-Jun Feng
Drugs that enhance the action of serotonin (5-hydroxytrypamine, 5-HT), including several selective serotonin reuptake inhibitors (SSRIs), reduce susceptibility to seizure-induced respiratory arrest (S-IRA) that leads to death in the DBA/1 mouse model of sudden unexpected ...

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Distinct behavioral and epileptic phenotype differences in 129/P mice compared to C57BL/6 mice subject to intraamygdala kainic acid-induced status epilepticus

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Luiz Fernando Almeida Silva, Tobias Engel, Cristina R. Reschke, Ronan M. Conroy, Elena Langa, David C. Henshall
Animal models of status epilepticus are important tools to understand the pathogenesis of epileptic brain injury and evaluate potential seizure-suppressive, neuroprotective, and antiepileptogenic treatments. Focal elicitation of status epilepticus by intraamygdala ...

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Semiological classification of psychogenic nonepileptic seizures

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Ali A. Asadi-Pooya, Jennifer Tinker, Elizabeth Fletman

Purpose
We classified patients with psychogenic nonepileptic seizures (PNESs) according to a newly proposed classification system. Then, we investigated the demographic and clinical differences between various classes of the patients.
Methods
We retrospectively investigated all patients with PNESs admitted to the Jefferson Comprehensive Epilepsy Center from ...

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Communicating diagnostic certainty of psychogenic nonepileptic seizures — a national study of provider documentation

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Hamada H. Altalib, Khalid Elzamzamy, Mary Jo Pugh, Javier Ballester Gonzalez, Kei-Hoi Cheung, Brenda T. Fenton, Robert D. Kerns, Cynthia A. Brandt, W Curt LaFrance
Management of psychogenic nonepileptic seizures (PNES) requires collaboration among and between health care professionals. Although criteria are ...

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Alcohol withdrawal in epileptic rats — Effects on postictal depression, respiration, and death

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Srinivasa P. Kommajosyula, Marcus E. Randall, Srinivasan Tupal, Carl L. Faingold
Patients with epilepsy are at risk of sudden unexpected death in epilepsy (SUDEP). The most common series of events in witnessed cases of SUDEP is a generalized convulsive seizure followed by terminal apnea. Risk factors for SUDEP include prolonged postictal depression ...

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