Temporal patterns of epileptiform discharges in genetic generalized epilepsies

Publication date: November 2016Source:Epilepsy & Behavior, Volume 64, Part A
Author(s): Udaya Seneviratne, Ray C. Boston, Mark Cook, Wendyl D’Souza

Objective
We sought to investigate the temporal patterns and sleep–wake cycle-related epileptiform discharges (EDs) in genetic generalized epilepsies (GGEs).
Methods
We studied 24-hour ambulatory electroencephalography (EEG) recordings of patients with GGE, diagnosed and classified according to the International League against Epilepsy criteria. ...

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Paraneoplastic epilepsy

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Anna Serafini, Rimas V. Lukas, Stephen VanHaerents, Peter Warnke, James X. Tao, Sandra Rose, Shasha Wu
Epilepsy can be a manifestation of paraneoplastic syndromes which are the consequence of an immune reaction to neuronal elements driven by an underlying malignancy affecting other organs and tissues. The antibodies commonly ...

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Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Shayan Amiri, Arya Haj-Mirzaian, Hossein Amini-khoei, Armin Shirzadian, Maryam Rahimi-Balaei, Ali Razmi, Hugo Bergen, Mojgan Rastegar, Nastaran Kordjazy, Arvin Haj-Mirzaian, Shahram Ejtemai-Mehr, Ahmad Reza Dehpour
In this study, we tested whether acute administration of lithium mitigates the deleterious ...

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Mortality in isodicentric chromosome 15 syndrome: The role of SUDEP

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Daniel Friedman, Alison Thaler, Jonathan Thaler, Samhitha Rai, Edwin Cook, Carolyn Schanen, Orrin Devinsky

Purpose
To ascertain the cause of mortality and incidence of sudden unexpected death in epilepsy (SUDEP) in patients with supernumerary isodicentric chromosome 15 (idic15).
Methods
Cases were obtained from those reported to the ...

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Age at onset and seizure frequency affect white matter diffusion coefficient in patients with mesial temporal lobe epilepsy

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Szilvia A. Nagy, Réka Horváth, Gábor Perlaki, Gergely Orsi, Péter Barsi, Flóra John, Andrea Horváth, Norbert Kovács, Péter Bogner, Hajnalka Ábrahám, Beáta Bóné, Csilla Gyimesi, Tamás Dóczi, József Janszky
In mesial temporal lobe epilepsy ...

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Differences between mesial and neocortical magnetic-resonance-imaging-negative temporal lobe epilepsy

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Irena Doležalová, Milan Brázdil, Jan Chrastina, Jan Hemza, Markéta Hermanová, Eva Janoušová, Marta Pažourková, Robert Kuba

Objective
The aim of this study was to assess clinical and electrophysiological differences within a group of patients with magnetic-resonance-imaging-negative temporal lobe epilepsy (MRI-negative TLE) according to seizure onset zone (SOZ) ...

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The effects of lacosamide on cognition, quality-of-life measures, and quality of life in patients with refractory partial epilepsy

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Marcelo E. Lancman, Evan J. Fertig, Robert W. Trobliger, Kenneth Perrine, Lorna Myers, Sloka S. Iyengar, Munazza Malik

Objective
The objective of this study was to examine cognitive and quality-of-life measures/quality of life outcomes with adjunctive lacosamide therapy in patients with treatment-resistant partial epilepsy.
Methods
This was ...

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High-dose versus low-dose valproate for the treatment of juvenile myoclonic epilepsy: Going from low to high

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Laura E. Hernández-Vanegas, Aurelio Jara-Prado, Adriana Ochoa, Nayelli Rodríguez y Rodríguez, Reyna Durón, Daniel Crail-Meléndez, Ma. Elisa Alonso, Antonio V. Delgado-Escueta, Iris E. Martínez-Juárez
Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy accounting for 3–12% of adult cases of epilepsy. Valproate has proven ...

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Safety and efficacy of perampanel in children and adults with various epilepsy syndromes: A single-center postmarketing study

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Kanwaljit Singh, Yash D. Shah, Daniel Luciano, Daniel Friedman, Orrin Devinsky, Sanjeev V. Kothare

Introduction
Perampanel is an AMPA receptor antagonist recently approved for the treatment of partial and generalized epilepsies with tonic–clonic seizures as an add-on therapy.
Methods
This single-center postmarketing study retrospectively evaluated the efficacy of perampanel ...

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Remission of epilepsy as a function of time

Publication date: August 2016Source:Epilepsy & Behavior, Volume 61
Author(s): Peter Wolf
The modalities and mechanisms of remission in epilepsy are largely unknown apart from certain self-limited syndromes. In an earlier investigation, therapeutic antiepileptic drug (AED) plasma levels were used as biomarkers of seizure propensity, and their course was monitored during slow stepwise drug withdrawal in seizure-free patients. The findings indicated that remission typically was a slow quantitative process taking ...

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