Abstract
Objective
Although temporal lobe epilepsy (TLE) is recognized as a system‐level disorder, little work has investigated pathoconnectomics from a dynamic perspective. By leveraging computational simulations that quantify patterns of information flow across the connectome, we tested the hypothesis that network communication is abnormal in this condition, studied the interplay between hippocampal‐ and network‐level disease effects, and assessed associations with cognition.
Methods
We simulated signal spreading via a linear threshold model that temporally evolves on a structural graph derived from diffusion‐weighted magnetic resonance imaging ...
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