Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

Focal cortical dysplasia (FCD) is the most common etiology of surgically-remediable epilepsy in children. Eighty-seven percent of patients with FCD develop epilepsy (75% is pharmacoresistant epilepsy [PRE]). Focal to bilateral tonic–clonic (FTBTC) seizures are associated with worse surgical outcomes. We hypothesized that children with FCD-related epilepsy with FTBTC seizures are more likely to develop PRE due to lesion interaction with restricted cortical neural networks.

Methods

Patients were selected retrospectively from radiology and surgical databases from Children’s National Hospital. Inclusion criteria: 3T magnetic ...

Abstract

Objective

Nonconvulsive status epilepticus (NCSE) is a frequent condition in the neurocritical care unit (NCCU) patient population, with high morbidity and mortality. We aimed to assess the validity of available outcome prediction scores for prognostication in an NCCU patient population in relation to their admission reason (NCSE vs. non-NCSE related).

Methods

All 196 consecutive patients diagnosed with NCSE during the NCCU stay between January 2010 and December 2020 were included. Demographics, Simplified Acute Physiology Score II (SAPS II), NCSE characteristics, and in-hospital and ...

Abstract

Objective

Individuals with epilepsy often have memory difficulties, and older adults with epilepsy are especially vulnerable, due to the additive effect of aging. The goal of this study was to assess factors that are associated with 24-hour memory retention in older adults with epilepsy.

Methods

55 adults with epilepsy, all over age 50, performed a declarative memory task involving the recall of the positions of 15 card pairs on a computer screen prior to a 24-hour ambulatory EEG. We assessed the percentage of ...

Abstract

Objective

Non convulsive status epilepticus (NCSE) is a frequent condition in the neurocritical care unit (NCCU) patient population with high morbidity and mortality. We aimed to assess the validity of available outcome prediction scores for prognostication in a NCCU patient population in relation to their admission reason (NCSE vs. non-NCSE related).

Methods

All 196 consecutive patients diagnosed with NCSE during the NCCU stay between 01.2010 and 12.2020 were included. Demographics, SAPS II, NCSE characteristics, in-hospital and 3 month outcome were extracted from the ...

Abstract

We have shown previously that the ketogenic diet (KD) is effective in reducing seizures associated with infantile spasms syndrome (ISS) and that this benefit is related to alterations in the gut microbiota. However, it remains unclear whether the efficacy of the KD persists after switching to a normal diet. Employing a neonatal rat model of ISS, we tested the hypothesis that the impact of the KD would diminish when switched to a normal diet. Following epilepsy induction, neonatal rats were ...

Abstract

Objective

Hispanics continue to face challenges when trying to access healthcare, including epilepsy care and genetic-related healthcare services. This study examined epilepsy genetic knowledge and beliefs in this historically underserved population.

Methods

Questionnaires were completed by 641 adults with epilepsy without identified cause, of whom 122 self-identified as Hispanic or Latino and 519 as non-Hispanic. Participants were asked about their views on the contribution of genetics to the cause of their epilepsy (“genetic attribution”), optimism for advancements in epilepsy genetic research (“genetic optimism”), ...

Abstract

Objective

There are limited data about the treatment and management of epilepsy with eyelid myoclonia (EEM). The objective of this study was to determine areas of consensus among an international panel of experts for the management of EEM (formerly known as Jeavons syndrome).

Methods

An international steering committee was convened of physicians and patients/caregivers with expertise in EEM. This committee summarized the current literature and identified an international panel of experts (comprising 25 physicians and five patients/caregivers). This panel participated in a modified ...