Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

Discrimination against persons with epilepsy (PWE) may still persist. The aim of the study was to examine whether epilepsy is an obstacle to desired friendship.

Methods

A factorial survey (vignettes), which is less biased by social desirability, was applied to PWE, their relatives, and lay persons. The vignettes described a person who was varied by the dimensions of age (younger, same age, older), gender (male, female), disease (healthy, mild epilepsy, severe epilepsy [generalized tonic-clonic seizures], diabetes), origin (German, non-German), contact (phone/internet, activities ...

Abstract

Task-based functional magnetic resonance imaging (tfMRI) has developed as a common alternative in epilepsy surgery to the intracarotid amobarbital procedure (IAP), also known as the Wada procedure. Prior studies have implicated tfMRI as a comparable predictor of postsurgical cognitive outcomes. However, the predictive validity of tfMRI has not been established. This preregistered systematic review and meta-analysis (CRD42020183563) synthesizes the literature predicting postsurgical cognitive outcomes in temporal lobe epilepsy (TLE) using tfMRI. PubMed and PsychINFO literature databases were queried for English-language ...

Abstract

Objective

Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous intracranial haemorrhage in older adults. Epilepsy represents a possible sequelae of the disease. To date studies on epilepsy in CAA are missing and the few data available mainly focus on CAA-related inflammation (CAA-ri), the inflammatory form of the disease.

Methods

In this retrospective observational study, we consecutively recruited CAA patients observed in a time span of ten years, collecting demographic, clinical, and instrumental data. Significant baseline characteristics were ...

Abstract

Objective

To determine duration of epileptic seizure types in patients who did not undergo withdrawal of antiseizure medication.

Methods

From a large, structured database of 11,919 consecutive, routine video-electroencephalograpy (EEG) recordings, labelled using the SCORE (Standardised Computer-Based Organised Reporting of EEG) system, we extracted and analysed 2,742 seizures. For each seizure type we determined median duration and range after removal of outliers (2.5-97.5 percentile). We used surface electromyography (EMG) for accurate measurement of short motor seizures.

Results

Myoclonic seizures last <150 ms, epileptic spasms 0.4-2 ...

Abstract

Objective

This study aimed to investigate the quantitative relationship between interictal ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) and interictal high frequency oscillations (HFOs) from stereoelectroencephalography (SEEG) recordings in refractory epilepsy patients.

Methods

We retrospectively included 32 patients. FDG-PET data were quantified through statistical parametric mapping (SPM) t-test modeling with normal controls. Interictal SEEG segments with four 10-min segments were randomly selected. HFO detection and classification procedures were automatically performed. Channel-based HFOs separating ripple (80-250Hz) and fast ripple (FR, 250-500Hz) counts were correlated with the ...

Abstract

Despite the widespread use of intraoperative electrocorticography (iECoG) during resective epilepsy surgery, there are conflicting data on its overall efficacy and inability to predict benefit per pathology. Given the heterogeneity of iECoG use in resective epilepsy surgery, it is important to assess the utility of interictal-based iECoG. This individual patient data (IPD) meta-analysis seeks to identify the benefit of iECoG during resective epilepsy surgery in achieving seizure freedom for various pathologies. Embase, Scopus, and PubMed were searched from inception to ...

Abstract

Objective

The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding to extracellularly released ATP. Expression of the P2X7R is increased in the brain in experimental and human epilepsy and genetic or pharmacologic targeting of the receptor can reduce seizure frequency and severity in preclinical models. Experimentally-induced seizures also increase levels of the P2X7R in blood. Here, we tested ¹⁸F-JNJ-64413739, a positron emission tomography (PET) P2X7R antagonist, as a potential non-invasive biomarker of seizure-damage and epileptogenesis.

Methods

Status epilepticus was induced via ...

Abstract

Objective

Infantile spasms are anis an epileptic encephalopathy of childhood, and its pathophysiology is largely unknown.We generated a heterozygous knock-in mouse with the human infantile spasms-associated de novo mutation GABRB3(c.A328G, p.N110D) to investigate its molecular mechanisms and to establish the Gabrb3
^+/N110D
knock-in mouse as a model of infantile spasm syndrome.

Methods

We used electroencephalography (EEG) and video monitoring to characterize seizure types, and a suite of behavioral tests to identify neurological and behavioral impairment in Gabrb3
^+/N110D

Abstract

Objective

Interictal spikes help localize seizure generators as part of surgical planning for drug-resistant epilepsy. However, there are often multiple spike populations whose frequencies change over time, influenced by brain state. Understanding state changes in spike rates will improve our ability to use spikes for surgical planning. Our goal was to determine the effect of sleep and seizures on interictal spikes, and to use sleep and seizure-related changes in spikes to localize the seizure onset zone.

Methods

We performed a retrospective analysis of ...