Abstract
Objective
Treatment with valproic acid (VPA) is associated with risk of liver toxicity. The aim of this study was to use a precision approach to investigate pharmacokinetic variability of both total and unbound serum concentrations of VPA and perform complementary biochemical analyses to evaluate possible markers of toxicity in a clinical setting.
Methods
Therapeutic drug monitoring (TDM) data (2018–2022) including total and free unbound serum concentrations of VPA, measurements of concomitantly used antiseizure medications, and biochemical analyses of ammonia and liver enzymes were ...
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