Clinical utility of intraoperative electrocorticography for epilepsy surgery: A systematic review and meta‐analysis

Abstract

Despite the widespread use of intraoperative electrocorticography (iECoG) during resective epilepsy surgery, there are conflicting data on its overall efficacy and inability to predict benefit per pathology. Given the heterogeneity of iECoG use in resective epilepsy surgery, it is important to assess the utility of interictal-based iECoG. This individual patient data (IPD) meta-analysis seeks to identify the benefit of iECoG during resective epilepsy surgery in achieving seizure freedom for various pathologies. Embase, Scopus, and PubMed were searched from inception to ...

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Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice

Abstract

Objective

The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding to extracellularly released ATP. Expression of the P2X7R is increased in the brain in experimental and human epilepsy and genetic or pharmacologic targeting of the receptor can reduce seizure frequency and severity in preclinical models. Experimentally-induced seizures also increase levels of the P2X7R in blood. Here, we tested 18F-JNJ-64413739, a positron emission tomography (PET) P2X7R antagonist, as a potential non-invasive biomarker of seizure-damage and epileptogenesis.

Methods

Status epilepticus was induced via ...

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Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms

Abstract

Objective

Infantile spasms are anis an epileptic encephalopathy of childhood, and its pathophysiology is largely unknown.We generated a heterozygous knock-in mouse with the human infantile spasms-associated de novo mutation GABRB3(c.A328G, p.N110D) to investigate its molecular mechanisms and to establish the Gabrb3
+/N110D
knock-in mouse as a model of infantile spasm syndrome.

Methods

We used electroencephalography (EEG) and video monitoring to characterize seizure types, and a suite of behavioral tests to identify neurological and behavioral impairment in Gabrb3
+/N110D

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Spike patterns surrounding sleep and seizures localize the seizure onset zone in focal epilepsy

Abstract

Objective

Interictal spikes help localize seizure generators as part of surgical planning for drug-resistant epilepsy. However, there are often multiple spike populations whose frequencies change over time, influenced by brain state. Understanding state changes in spike rates will improve our ability to use spikes for surgical planning. Our goal was to determine the effect of sleep and seizures on interictal spikes, and to use sleep and seizure-related changes in spikes to localize the seizure onset zone.

Methods

We performed a retrospective analysis of ...

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Latent class analysis of eHealth behaviors among adults with epilepsy

Abstract

Objective

The objective of this study was to determine the proportions of uptake and factors associated with electronic health (eHealth) behaviors among adults with epilepsy.

Methods

The 2013, 2015 and 2017 National Health Interview Surveys were analyzed. We assessed the proportions of use of five domains of eHealth in those with epilepsy: looked up health information on the internet, filled a prescription on the internet, scheduled a medical appointment on the internet, communicated with a healthcare provider via email, and used chat groups ...

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Daily resting‐state intracranial EEG connectivity for seizure risk forecasts

Abstract

Forecasting seizure risk aims to detect pro-ictal states in which seizures would be more likely to occur. Classical seizure prediction models are trained over long-term EEG recordings to detect specific preictal changes for each seizure, independently of those induced by shifts in states of vigilance. A daily single measure – during a vigilance-controlled period – to estimate the risk of upcoming seizure(s) would be more convenient. Here, we evaluated whether intracranial EEG connectivity (phase-locking value), estimated from daily vigilance-controlled resting-state ...

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Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex

Abstract

Objective

The objectives of this study were to assess the accuracy of parental seizure detection in infants with antenatally diagnosed tuberous sclerosis complex (TSC), and to document the total seizure burden (clinical and subclinical) in those patients who met criteria for prolonged electroencephalography (EEG) recording.

Methods

Consecutive infants at a single institution with antenatally diagnosed TSC who met criteria for prolonged video-EEG (vEEG) were recruited to this study. The vEEG data were reviewed and when a seizure was identified on EEG, the video ...

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Development of a core outcome set for quality of life for adults with drug‐resistant epilepsy: A multistakeholder Delphi consensus study

Abstract

Objective

In 2017, the American Academy of Neurology (AAN) convened the AAN Quality Measurement Set working group to define the improvement and maintenance of quality of life (QOL) as a key outcome measure in epilepsy clinical practice. A core outcome set (COS), defined as an accepted, standardized set of outcomes that should be minimally measured and reported in an area of health care research and practice, has not previously been defined for QOL in adult epilepsy.

Methods

A cross-sectional Delphi consensus study was ...

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Responsive neurostimulation with low‐frequency stimulation

Abstract

Deep brain stimulation and responsive neurostimulation (RNS) use high-frequency stimulation (HFS) per the pivotal trials and manufacturer-recommended therapy protocols. However, not all patients respond to HFS. In this retrospective case series, 10 patients implanted with the RNS System were programmed with low-frequency stimulation (LFS) to treat their seizures; nine of these patients were previously treated with HFS (100 Hz or greater). LFS was defined as frequency < 10 Hz. Burst duration was increased to at least 1000 ms. With HFS, patients had a median ...

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First‐line levetiracetam versus enzyme‐inducing antiseizure medication in glioma patients with epilepsy

Abstract

Objective

This study aimed to directly compare the effectiveness of first-line monotherapy levetiracetam (LEV) versus enzyme-inducing antiseizure medications (EIASMs) in glioma patients.

Methods

In this nationwide retrospective observational cohort study, Grade 2–4 glioma patients were included, with a maximum duration of follow-up of 36 months. Primary outcome was antiseizure medication (ASM) treatment failure for any reason, and secondary outcomes were treatment failure due to uncontrolled seizures and due to adverse effects. For estimation of the association between ASM treatment and ASM treatment failure, multivariate ...

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