Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

To evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of lacosamide (LCM) (up to 12 mg/kg/day or 600 mg/day) as adjunctive therapy in pediatric patients with epilepsy syndromes associated with generalized seizures.

Methods

Phase 2, multicenter, open-label exploratory trial (SP0966; NCT01969851; 2012-001446-18) of oral LCM for epilepsy syndromes associated with generalized seizures in pediatric patients ≥1 month to <18 years of age taking one to three concomitant antiseizure medications. The trial comprised a 6-week prospective baseline period, 6-week flexible titration period, and 12-week maintenance period.

Results

Fifty-five patients ...

Abstract

Objective

We conducted a systematic review and meta-analysis to evaluate postoperative seizure and memory outcomes of temporal lobe epilepsy with different hippocampal sclerosis (HS) subtypes classified by ILAE Consensus Guidelines in 2013.

Method

Following the PRISMA and MOOSE guidelines, we searched PubMed, Embase, Web of Science, and Cochrane Library from January 1, 2013 to August 6, 2023. Observational studies reporting seizure and memory outcomes among different HS subtypes were included. We used the Newcastle-Ottawa scale to assess the risk of bias and the ...

Abstract

Objective

Thalamic deep brain stimulation (DBS) is an effective therapeutic option in patients with drug-resistant epilepsy. Recent DBS devices with sensing capabilities enable chronic, outpatient local field potential (LFP) recordings. Whereas beta oscillations have been demonstrated to be a useful biomarker in movement disorders, the clinical utility of DBS sensing in epilepsy remains unclear. Our aim was to determine LFP features that distinguish ictal from inter-ictal states, which may aid in tracking seizure outcomes with DBS.

Methods

Electrophysiology data were obtained from DBS ...

Abstract

Objective

While interoceptive abnormality in patients with functional seizure (FS) has been demonstrated using explicit tasks, implicit measurements of interoception such as the effect of interoception on perceptual brain processes, have not been investigated. It has been shown that perception
is
normally modulated by interoceptive signals related to the
different phases (systole v diastole) of the
cardiac cycle (cardiac modulation
effect
). Given our previous findings using ...

Abstract

Most cases with new-onset refractory status epilepticus (NORSE) remain cryptogenic despite extensive diagnostic work-up. The aim of this study was to analyse the etiology and clinical features of NORSE and investigate known or potentially novel autoantibodies in cryptogenic NORSE (cNORSE). We retrospectively assessed the medical records of adults with status epilepticus at a Swiss tertiary referral center between 2010 and 2021. Demographic, diagnostic, therapeutic and outcome parameters were characterized. We performed post-hoc screening for known or potentially novel autoantibodies including ...

Abstract

The recent explosion of epilepsy genetic testing has created challenges for interpretation of gene variants. Assessments of the functional consequences of genetic variants either by predictive or experimental strategies can contribute to estimating pathogenicity, but there is no consensus on which approach is best. The Special Interest Group on Epilepsy Genetics hosted a session during the Annual American Epilepsy Society Meeting in December 2022 to discuss this topic. The session featured a debate of the relative advantages and limitations of ...

Abstract

Objective

To evaluate the long-term safety, tolerability, and efficacy of adjunctive brivaracetam (BRV) treatment in pediatric patients with epilepsy.

Methods

Phase 3, open-label, multicenter, long-term follow-up trial (N01266; NCT01364597; patients aged 1 month to <17 years at core trial entry; direct enrollers aged 4 to <17 years) treated with BRV. Outcomes included treatment-emergent adverse events (TEAEs), behavior assessments (Achenbach Child Behavior Checklist [CBCL]; Behavior Rating Inventory of Executive Function [BRIEF-P/BRIEF]), and efficacy outcomes (percent change in focal seizure frequency, 50% responder rate for all seizure ...

Abstract

The study aimed to group acute symptomatic aetiologies of consecutive episodes of status epilepticus (SE) into different subcategories and explore their associations with clinical outcome. Aetiologies were firstly categorized as “acute”, “remote”, “progressive”, “SE in defined electroclinical syndromes”, and “unknown”. Four subcategories of acute aetiologies were then defined: i) withdrawal, or low levels, or inappropriate prescription of antiseizure medications, or sleep deprivation in patients with pre-existing epilepsy; ii) acute insults to central nervous system (CNS) (“acute-primary CNS”); iii) CNS pathology ...

Abstract

Objective

Ictal injuries have long been considered typical signs of epileptic seizures. However, studies have shown that patients with functional seizures (FS) – also named psychogenic non-epileptic seizures – can also present these signs, misleading physicians and delaying a correct diagnosis. This systematic review aimed to assess the prevalence of injuries from FS.

Methods

A literature search was performed in PubMed, Embase, LILACS, Scopus, Web of Science, PsycINFO, Google Scholar, OpenGrey, and ProQuest. Observational studies were included. The risk of bias was assessed ...