Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Sleep and wake are defined through physiological and behavioral criteria and can be typically separated into NREM sleep stages N1, N2, and N3, REM sleep and wake. Sleep and wake states are not homogenous in time. Their properties vary during the night and day cycle. Given that brain activity changes as a function of NREM, REM, and wake during the night and day cycle, are seizures more likely to occur during NREM, REM, or wake at a specific time? More ...

Abstract

Mental health comorbidities are prevalent and problematic in patients with seizures but often suboptimally managed. To address common gaps in care, the Integrated Mental Health Care Pathways Task Force of the International League Against Epilepsy (ILAE) Psychiatry Commission was tasked with providing education and guidance on the integration of mental health management (e.g., screening, referral, treatment) into routine seizure care. This report aims to describe a variety of established services in this area, with a specific focus on psychological care ...

Abstract

Objective

Identifying abnormalities in interictal intracranial EEG, by comparing patient data to a normative map, has shown promise for the localization of epileptogenic tissue and prediction of outcome. The approach typically uses short interictal segments of around one minute. However, the temporal stability of findings has not been established.

Methods

Here, we generated a normative map of iEEG in non-pathological brain tissue from 249 patients. We computed regional band power abnormalities in a separate cohort of 39 patients for the duration of their ...

Abstract

Objective

We assessed mortality, sudden unexpected death in epilepsy (SUDEP), and standardized mortality ratio (SMR) among adults treated with cenobamate during the cenobamate clinical development program.

Methods

We retrospectively analyzed deaths among all adults with uncontrolled focal (focal to bilateral tonic-clonic [FBTC], focal impaired awareness, focal aware) or primary generalized tonic-clonic (PGTC) seizures who received ≥1 dose of adjunctive cenobamate in completed and ongoing phase 2 and 3 clinical studies. In patients with focal seizures from completed studies, median baseline seizure frequencies ranged ...

Abstract

Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the quality of life and associated with several comorbidities. Sleep impairment is a frequent condition in patients with epilepsy (PWE), and the relation between sleep and epilepsy has been considered bidirectional since one can significantly influence the other, and vice versa. The orexin system has been described more than 20 years ago and is implicated in several neuro-biological functions, other than in controlling the sleep-wake cycle. Considering the relation ...

Abstract

Objective

KCNA1 mutations are associated with a rare neurological movement disorder known as episodic ataxia type 1 (EA1), and epilepsy is a common comorbidity. Current medications only provide partial relief to ataxia and/or seizures, making new drugs needed. Here, we characterized zebrafish kcna1a
^-/-
as a model of EA1 with epilepsy and compared the efficacy of the first-line therapy carbamazepine in kcna1a
^-/-
zebrafish to Kcna1
^-/-
rodents.

Methods

CRISPR/Cas9 mutagenesis was used to introduce a mutation in the sixth ...

Abstract

Objective

Previous studies suggest that intermittent deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) affects physiological sleep architecture. Here, we investigated the impact of continuous ANT-DBS on sleep in epilepsy patients in a multicenter cross-over study in ten patients.

Methods

We assessed sleep stage distribution, delta power, delta energy, and total sleep time (TST) in standardized 10/20 polysomnography (PSG) investigations before and 12 months after DBS lead implantation.

Results

In contrast to previous studies, we found no disruption of sleep architecture ...

Abstract

Objective:

Gain of function variants in the sodium activated potassium channel KCNT1 have been associated with pediatric epilepsy disorders. Here we systematically examine a spectrum of KCNT1 variants and establish their impact on channel function in multiple cellular systems.

Methods

KCNT1 variants identified from published reports and genetic screening of pediatric epilepsy patients were expressed in Xenopus oocytes and HEK cell lines. Variant impact on current magnitude, current-voltage relationships and sodium ion modulation were examined.

Results

We determined basic properties of KCNT1 in Xenopus oocyte ...