Defining the latent period of epileptogenesis and epileptogenic zone in a focal cortical dysplasia type II (FCDII) rat model

Summary

Objectives

Focal cortical dysplasia type II (FCDII) is one of the most common underlying pathologies in patients with drug‐resistant epilepsy. However, mechanistic understanding of FCDII fails to keep pace with genetic discoveries, primarily due to the significant challenge in developing a clinically relevant animal model. Conceptually and clinically important questions, such as the unknown latent period of epileptogenesis and the controversial epileptogenic zone, remain unknown in all experimental FCDII animal models, making it even more challenging to investigate the underlying epileptogenic ...

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Social outcome and psychiatric comorbidity of generalized epilepsies – A case‐control study

SUMMARY

Objective

To investigate social outcome and psychiatric comorbidity of patients with idiopathic/genetic generalized epilepsies (IGEs) and its subtypes (epilepsy with generalized tonic‐clonic seizures alone [EGTCS], juvenile absence epilepsy [JAE], and juvenile myoclonic epilepsy [JME]).

Methods

A cohort of 402 adult patients with IGE from the Danish island Funen was matched with 4020 randomly selected geography‐, age‐, and sex‐matched controls via the Danish Civil Registration System. Based on register data, we compared social status measured by cohabitant status, educational attainment, income, affiliation to labor ...

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Topographical reorganization of brain functional connectivity during an early period of epileptogenesis

Abstract

Objective

The current study aims to investigate functional brain network representations during the early period of epileptogenesis.

Methods

Eighteen rats with the intrahippocampal kainate model of mesial temporal lobe epilepsy were used for this experiment. Functional magnetic resonance imaging (fMRI) measurements were made 1 week after status epilepticus, followed by 2–4‐month electrophysiological and video monitoring. Animals were identified as having (1) developed epilepsy (E+, n = 9) or (2) not developed epilepsy (E−, n = 6). Nine additional animals served as controls. Graph theory analysis was performed ...

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Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Summary

Objective

This study was undertaken to identify clinical factors associated with seizure freedom after magnetic resonance‐guided laser interstitial thermal therapy (MRgLiTT) in temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (MTS).

Methods

We identified 56 patients with magnetic resonance imaging‐defined MTS who underwent MRgLiTT with at least 1 year of follow‐up. Primary outcome was seizure freedom at 1 year. We examined the association of seizure freedom and the following clinical factors: age at surgery, gender, history of febrile seizures, history of focal to ...

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Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool

Abstract

Objective

To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy.

Methods

We analyzed 1267 hemispheric surgeries performed in pediatric participants across 32 centers and 12 countries to identify predictors of seizure freedom at 3 months after surgery. A multivariate logistic regression model was developed based on 70% of the dataset (training set) and validated on 30% of the dataset (validation set). Missing data were handled using multiple imputation techniques.

Results

Overall, 817 ...

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Synergistic effect of sleep depth and seizures correlates with postictal heart rate

ABSTRACT

Our objective was to determine the effect of sleep on heart rate following a recorded seizure. We prospectively acquired heart rate data in hospitalized epilepsy monitoring unit patients. We analyzed heart rate trends for multiple seizures (n = 101) in patients (n = 42) with electroencephalographically confirmed events. The patient’s sleep state was scored for the 5 min preceding each seizure and correlated with the postictal nadir heart rate (PINHR). The depth of sleep during the 5 min before a seizure correlated (correlation coefficient ...

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Altered communication dynamics reflect cognitive deficits in temporal lobe epilepsy

Abstract

Objective

Although temporal lobe epilepsy (TLE) is recognized as a system‐level disorder, little work has investigated pathoconnectomics from a dynamic perspective. By leveraging computational simulations that quantify patterns of information flow across the connectome, we tested the hypothesis that network communication is abnormal in this condition, studied the interplay between hippocampal‐ and network‐level disease effects, and assessed associations with cognition.

Methods

We simulated signal spreading via a linear threshold model that temporally evolves on a structural graph derived from diffusion‐weighted magnetic resonance imaging ...

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Postpartum psychiatric readmissions: A nationwide study in women with and without epilepsy

Abstract

Objective

To assess whether epilepsy is associated with increased odds of 30‐day readmission due to psychiatric illness during the postpartum period.

Methods

The 2014 Nationwide Readmissions Database and the International Classification of Disease, Ninth Revision, Clinical Modification codes were used to identify postpartum women up to 50 years old in the United States, including the subgroup with epilepsy. The primary outcome was 30‐day readmission and was categorized as (1) readmission due to psychiatric illness, (2) readmission due to all other causes, or (3) no ...

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