Epilepsia. Official Journal of the International League Against Epilepsy

To search for new therapies aimed at ameliorating the neurologic symptoms and epilepsy developing in patients with Lafora disease.

Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes. Epm2a^−/− and Epm2b^−/− mice display neurologic and behavioral abnormalities similar to those found in patients. Selenium is a potent antioxidant and its deficiency has been related to the development of certain diseases, including epilepsy. In this study, we investigated whether sodium selenate treatment improved ...

To search for new therapies aimed at ameliorating the neurologic symptoms and epilepsy developing in patients with Lafora disease.

Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes. Epm2a^−/− and Epm2b^−/− mice display neurologic and behavioral abnormalities similar to those found in patients. Selenium is a potent antioxidant and its deficiency has been related to the development of certain diseases, including epilepsy. In this study, we investigated whether sodium selenate treatment improved ...

To search for new therapies aimed at ameliorating the neurologic symptoms and epilepsy developing in patients with Lafora disease.

Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes. Epm2a^−/− and Epm2b^−/− mice display neurologic and behavioral abnormalities similar to those found in patients. Selenium is a potent antioxidant and its deficiency has been related to the development of certain diseases, including epilepsy. In this study, we investigated whether sodium selenate treatment improved ...

The diagnosis of epilepsy cannot be reliably made prior to a patient’s second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level–dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure.

We examined ...

The diagnosis of epilepsy cannot be reliably made prior to a patient’s second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level–dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure.

We examined ...

We determined the role of the neurosteroid-sensitive δ subunit–containing γ-aminobutyric acid A receptors (δ-GABARs) in epileptogenesis.

Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video–electroencephalography (EEG) monitoring. Finasteride was administered to inhibit neurosteroid synthesis. The total and surface protein expression of hippocampal δ, α4, and γ2 GABAR subunits was studied using biotinylation assays and Western blotting. Neurosteroid potentiation of the tonic currents of dentate granule cells (DGCs) was ...

We determined the role of the neurosteroid-sensitive δ subunit–containing γ-aminobutyric acid A receptors (δ-GABARs) in epileptogenesis.

Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video–electroencephalography (EEG) monitoring. Finasteride was administered to inhibit neurosteroid synthesis. The total and surface protein expression of hippocampal δ, α4, and γ2 GABAR subunits was studied using biotinylation assays and Western blotting. Neurosteroid potentiation of the tonic currents of dentate granule cells (DGCs) was ...