Lacosamide in the treatment of patients with epilepsy and intellectual disabilities: A long-term study of 136 patients

Summary

Objective

This study aimed to analyze the retention rate of lacosamide (LCM) in patients with epilepsy and intellectual disabilities (IDs), to identify factors influencing retention rate, and to investigate the LCM retention rate with and without concomitant sodium channel blocker (SCB). We hypothesized that the retention rate of LCM with concomitant SCB would be lower than without SCB.

Methods

Using the Kaplan-Meier estimator, we conducted a monocentric, retrospective, observational, open-label study to evaluate LCM retention rates in patients with ...

Seguir leyendo →
0

Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study

Summary

Objective

To analyze the attitude and results of Italian epilepsy surgery centers in the surgical management of “low grade epilepsy associated neuroepithelial tumors” (LEATs).

Methods

We conducted a retrospective study enrolling 339 consecutive patients with LEATs who underwent surgery between January 2009 and June 2015 at eight Italian epilepsy surgery centers. We compared demographic, clinical, pathologic, and surgical features of patients with favorable (Engel class I) and unfavorable (Engel class II, III, and IV) seizure outcome. In addition, we ...

Seguir leyendo →
0

Cognitive functioning in children with self-limited epilepsy with centrotemporal spikes: A systematic review and meta-analysis

Summary

Objective

It is now well appreciated that benign epilepsy with centrotemporal spikes (BECTS, or more recently, ECTS) is associated with a range of cognitive and behavioral disturbances. Despite our improved understanding of cognitive functioning in ECTS, there have been to date no efforts to quantitatively synthesize the available literature within a comprehensive cognitive framework.

Methods

The present systematic review and meta-analysis was conducted according to PRISMA guidelines. Forty-two case–control samples met eligibility criteria comprising a total of 1,237 children ...

Seguir leyendo →
0

Cognitive functioning in children with self-limited epilepsy with centrotemporal spikes: A systematic review and meta-analysis

Summary

Objective

It is now well appreciated that benign epilepsy with centrotemporal spikes (BECTS, or more recently, ECTS) is associated with a range of cognitive and behavioral disturbances. Despite our improved understanding of cognitive functioning in ECTS, there have been to date no efforts to quantitatively synthesize the available literature within a comprehensive cognitive framework.

Methods

The present systematic review and meta-analysis was conducted according to PRISMA guidelines. Forty-two case–control samples met eligibility criteria comprising a total of 1,237 children ...

Seguir leyendo →
0

Long-term applicability of the new ILAE definition of epilepsy. Results from the PRO-LONG study

Summary

Objective

The new epilepsy definition adopted by the International League Against Epilepsy (ILAE) includes patients with one unprovoked seizure with a probability of further seizures, similar to the general recurrence risk after two unprovoked seizures, occurring in a 10-year period. Long-term follow-up of patients diagnosed after a single seizure is needed to assess the applicability of the new epilepsy definition in clinical practice.

Methods

Patients with newly diagnosed epilepsy were recruited retrospectively with a minimum follow-up of 10 years. Patients ...

Seguir leyendo →
0

Interactions between cannabidiol and commonly used antiepileptic drugs

Summary

Objective

To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored to identify interactions between CBD and AEDs.

Methods

In 39 adults and 42 children, CBD dose was started at 5 mg/kg/day and increased every 2 weeks by 5 mg/kg/day up to a maximum of 50 mg/kg/day. Serum AED levels were obtained at baseline prior to CBD initiation and at ...

Seguir leyendo →
0

Postoperative seizure freedom does not normalize altered connectivity in temporal lobe epilepsy

Summary

Objectives

Specific changes in the functional connectivity of brain networks occur in patients with epilepsy. Yet whether such changes reflect a stable disease effect or one that is a function of active seizure burden remains unclear. Here, we longitudinally assessed the connectivity of canonical cognitive functional networks in patients with intractable temporal lobe epilepsy (TLE), both before and after patients underwent epilepsy surgery and achieved seizure freedom.

Methods

Seventeen patients with intractable TLE who underwent epilepsy surgery with Engel ...

Seguir leyendo →
0

Postoperative seizure freedom does not normalize altered connectivity in temporal lobe epilepsy

Summary

Objectives

Specific changes in the functional connectivity of brain networks occur in patients with epilepsy. Yet whether such changes reflect a stable disease effect or one that is a function of active seizure burden remains unclear. Here, we longitudinally assessed the connectivity of canonical cognitive functional networks in patients with intractable temporal lobe epilepsy (TLE), both before and after patients underwent epilepsy surgery and achieved seizure freedom.

Methods

Seventeen patients with intractable TLE who underwent epilepsy surgery with Engel ...

Seguir leyendo →
0

Caring for transgender patients with epilepsy

Summary

Objective

Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3–0.9% of the world’s population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy.

Methods

We performed literature searches on the following terms: transgender AND epilepsy, transgender AND neurology, gender dysphoria AND epilepsy, gender dysphoria AND neurology. We also performed literature searches for common feminizing or masculinizing treatment regimens, and searched for interactions of ...

Seguir leyendo →
0

Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy

Summary

Objective

Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE]). Traditional antiepileptic drugs are effective in about 55% of patients, whereas the rest remains refractory. One of the key pathogenetic mechanisms is a gain of function of neuronal nicotinic acetylcholine receptors (nAChRs) containing the mutated α4 or β2 subunits. Fenofibrate, a common lipid-regulating drug, is an agonist at peroxisome proliferator-activated ...

Seguir leyendo →
0
Página 220 de 273 «...190200210218219220221222...»