Summary
Objective
To search for new therapies aimed at ameliorating the neurologic symptoms and epilepsy developing in patients with Lafora disease.
Methods
Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes. Epm2a−/− and Epm2b−/− mice display neurologic and behavioral abnormalities similar to those found in patients. Selenium is a potent antioxidant and its deficiency has been related to the development of certain diseases, including epilepsy. In this study, we investigated whether sodium selenate treatment improved ...
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