Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

Although the role of subcortical structures in the generation of epileptic spasms has been proposed, supporting evidence remains limited. This study aimed to provide neurophysiological evidence of thalamocortical network involvement during epileptic spasms.

Methods

We analyzed four patients (ages 2.7–16.9 years) with epileptic spasms who underwent intracranial electroencephalography (EEG) monitoring with thalamic sampling in preparation for potential neurostimulation. Epileptic spasms were initially assessed using visual inspection and time–frequency analysis. We then evaluated undirected connectivity through coherence analysis and directed connectivity using spectral Granger ...

Abstract

Objective

Although previous research shows that generalized and focal epilepsies have at least some distinct genetic influences, it remains uncertain why some families manifest both types of epilepsy. We tested two hypotheses: (1) families with both generalized and focal epilepsy carry separate risk alleles for both types; and (2) within mixed families, the type of epilepsy each individual manifests is influenced by the relative burden of separate risk alleles for generalized epilepsies and focal epilepsies.

Methods

The Epi4K cohort included 711 individuals with ...

Abstract

Despite significant research into more flexible methods of ketogenic diet therapy initiation, there is only limited literature on the best practices to discontinue it. Both tradition and guidelines suggest weaning this treatment over 2–3 months; however, a more abrupt discontinuation has also been reported. Fifteen children and adults on ketogenic diet therapy, with various levels of seizure control, had their ketogenic diet therapy immediately discontinued. All were coincidentally admitted to inpatient units (typically an epilepsy monitoring unit), with intravenous access and ...

Abstract

Objective

Patients with tuberous sclerosis complex (TSC)-related epilepsy often have drug-refractory epilepsy and numerous potential epileptogenic tubers. Current clinical methods target tubers for resection, but prediction of resulting seizure relief is difficult. This study describes implementation of lesion network mapping in TSC patients undergoing epilepsy surgery to associate resection zone with seizure outcomes.

Methods

Thirty-nine consecutive patients with TSC who underwent invasive electroencephalography (EEG) and resection or ablation of the seizure onset zone were included. After preprocessing, each resection zone was delineated as ...

Abstract

Objective

Despite extensive studies about the direct effect of stroke severity on poststroke epilepsy (PSE), the pathway of this relationship remains unclear. We examined whether stroke-associated infection (SAI) and early seizure (ES) mediate the association between stroke severity and PSE.

Methods

Patients with ischemic stroke from two tertiary hospitals in China were included in our retrospective cohort study. PSE was identified through telephone interviews based on a validated questionnaire and supplemented by a review of medical records. Stroke severity was measured using the ...

Abstract

Objective

Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy caused by SCN1A haploinsufficiency in the majority of cases. Caregivers of adults with DS often complain about the loss of previously acquired skills. We set out to explore these perceptions and determine whether abnormalities reported were detectable in validated tests. We also investigated possible correlations between symptoms, age, and exposure to sodium channel blockers (SCBs).

Methods

This cross-sectional, multicenter study used the Vineland Adaptive Behavior Scales, 3rd edition (raw scores) for behavior ...

Abstract

Objective

Epilepsy surgery is a standard treatment for drug-resistant epilepsy, resulting in seizure freedom in a significant number of cases. Although frequently performed for low-grade brain tumors, it is rarely considered for high-grade tumors, despite the impact of chronic epilepsy on quality of life and cognition.

Methods

This retrospective multicenter study across 43 European centers evaluated epilepsy surgery outcomes in children with ...