Summary
Objective
In humans, mutations of the γ‐aminobutyric acid receptor subunit 1 (GABRA1) cause either mild or severe generalized epilepsy. Although these epilepsy‐causing mutations have been shown to disrupt the receptor activity in vitro, their in vivo consequences on brain development and activity are not known. Here, we aim at unraveling the epileptogenesis mechanisms of GABRA1 loss of function.
Methods
We generated a gabra1
−/−
zebrafish mutant line displaying highly penetrant epileptic seizures. We sought to identify ...
NOV