Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

This study was undertaken to assess the impact of surgical treatment on the adaptive abilities of children with drug-resistant epilepsy (DRE) and moderate or severe developmental delays, and to identify factors that could potentially predict adaptive outcomes following epilepsy surgery.

Methods

A retrospective observational cohort study was conducted involving 130 pediatric patients with DRE treated in the Ribeirão Preto Epilepsy Surgery Program of the University of São Paulo between 1996 and 2019. Patients underwent comprehensive preoperative evaluations, including neurological, psychiatric, social, and ...

Abstract

Objective

Hypothalamic hamartomas (HHs) are developmental malformations associated with focal epilepsy. We investigated the patterns of gray matter morphology and cerebral metabolism in individuals with HHs, with and without focal to bilateral tonic–clonic seizures (FBTCSs), aiming to clarify the accompanying network abnormalities.

Methods

We analyzed magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (PET) data from 59 patients with HHs (28 with FBTCSs, 31 without), as well as MRI data from 30 healthy controls (HCs) and PET data from 45 HCs. We ...

Abstract

Objective

This study was undertaken to investigate diagnostic delay in adolescent onset focal epilepsy, including reasons for longer delays and associated morbidities.

Methods

Secondary analysis was done using enrollment data from the Human Epilepsy Project, a multi-institutional cohort including 34 sites in the USA, Canada, Finland, Austria, and Australia (2012–2017). Participants were aged 11–64 years at enrollment and within 4 months of treatment initiation for newly diagnosed focal epilepsy. Participants with seizure onset at age ≤ 21 years were evaluated. Data included seizure diaries documenting onset, frequency, ...

Abstract

Objective

This study aimed to evaluate the effectiveness of current neuropsychology referral methods for children with epilepsy and develop data-informed recommendations for use of performance-based cognitive screening measures to improve these processes.

Methods

Children with epilepsy who had been referred to neuropsychology (n = 51) or had never been referred (n = 34) completed four brief tablet-based screening tests from the National Institutes of Health Toolbox Cognition Battery along with a comprehensive neuropsychological test battery. Demographics, medical information, and parent questionnaires were gathered.

Results

Mean performance on the neuropsychological ...

Abstract

Objective

The circadian rhythm synchronizes physiological and behavioral patterns with the 24-h light–dark cycle. Disruption to the circadian rhythm is linked to various health conditions, although optimal methods to describe these disruptions remain unclear. An emerging approach is to examine the intraindividual variability in measurable properties of the circadian rhythm over extended periods. Epileptic seizures are modulated by circadian rhythms, but the relevance of circadian rhythm disruption in epilepsy remains unexplored. Our study investigates intraindividual circadian variability in epilepsy and its ...

Abstract

Objective

Cortical delta band (1–4 Hz) activity is considered a biomarker for states of altered consciousness, with increased delta power observed during anesthesia, sleep, coma, and delirium. The current study sought to characterize delta power following electrode implantation with respect to patient demographics and clinical characteristics as well as type and duration of surgery.

Methods

Participants were 25 adult neurosurgical patients implanted with intracranial electrodes for clinical monitoring of their epilepsy. Resting state cortical activity was recorded at multiple occasions over the course of ...

Abstract

Objective

To develop and validate a wrist-worn accelerometer-based, deep-learning tunable algorithm for the automated detection of generalized or bilateral convulsive seizures (CSs) to be integrated with off-the-shelf smartwatches.

Methods

We conducted a prospective multi-center study across eight European epilepsy monitoring units, collecting data from 384 patients undergoing video electroencephalography (vEEG) monitoring with a wrist-worn three dimensional (3D)–accelerometer sensor. We developed an ensemble-based convolutional neural network architecture with tunable sensitivity through quantile-based aggregation. The model, referred to as Episave, used accelerometer amplitude as input. ...

Abstract

Objective

We aimed to assess the prevalence, clinical characteristics, and risk factors for psychosis in a cohort of people with epilepsy in West China.

Methods

We used retrospective information from databases of three tertiary epilepsy centers, which included follow-up records from 2006 onward. Those with complete baseline data and at least one follow-up record were included. A psychiatrist confirmed the diagnosis of psychosis. Psychiatric features were evaluated using the Brief Psychiatric Rating Scale, Scale for the Assessment of Positive Symptoms, and Scale for ...