Neonatal vitamin D status and risk of childhood epilepsy

Abstract

Objective

Epilepsy is a nervous system abnormality that may be caused by unknown exposures during fetal development. Studies have shown neuroprotective effects of early exposure to vitamin D in other neurological disorders, and seasonal variation in birth of children with epilepsy. We aimed to investigate if neonatal 25(OH)D3 was associated with risk of childhood epilepsy.

Methods

This case‐cohort study compared neonatal 25(OH)D3 levels from children with epilepsy (n = 403) and a random selected cohort of controls (n = 1163), assessing the hazard of first epilepsy diagnosis ...

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New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study

Abstract

Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID‐19). This multicenter retrospective study enrolled people with COVID‐19 from January 18 to February 18, 2020 at 42 government‐designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had ...

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Characterization of organophosphate‐induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure

Abstract

Organophosphate (OP) compounds constitute a class of highly toxic molecules, characterized by irreversible cholinesterase (ChE) inhibition. Being either pesticides or chemical warfare agents, they present a major health issue in some countries, as well as a terrorist or military threat. Prompted by the need for suitable animal models to test novel medical countermeasures, we developed a new convulsive mouse model of OP poisoning using diisopropylfluorophosphate (DFP). Using electrocorticography (ECoG), we analyzed seizure and status epilepticus (SE) occurrences, as well as ...

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Severe psychological distress among epilepsy patients during the COVID‐19 outbreak in southwest China

Summary

Objective

To compare the severity of psychological distress between epilepsy patients and healthy controls during the COVID‐19 outbreak in southwest China, as well as identify potential risk factors of severe psychological distress among epilepsy patients.

Methods

This cross‐sectional case control study examined a consecutive sample of patients older than 15 years treated at the epilepsy center of West China Hospital between 01 and 29 February 2020. As controls, sex‐ and age‐matched healthy visitors of inpatients (unrelated to the patients) were also enrolled during ...

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Pharmacokinetics and safety of VALTOCO (NRL‐1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri‐ictal) and nonseizure (interictal) conditions: A phase 1, open‐label study

Abstract

Objective

To assess pharmacokinetics and safety of diazepam nasal spray (NRL‐1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states.

Methods

A single dose of diazepam nasal spray (5, 10, 15, or 20 mg based on weight) was administered during each of two conditions (ictal/peri‐ictal and interictal condition) to patients 6‐65 years old with partial or generalized epilepsy with motor seizures or seizures with clear alteration of awareness; a second dose was permitted if needed for persistent seizures. Dosing could be ...

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Interactions between in vivo neuronal‐glial markers, side of hippocampal sclerosis, and pharmacoresponse in temporal lobe epilepsy

Abstract

Objective

To evaluate the interactions of metabolic neuronal‐glial changes with the presence and hemispheric‐side of hippocampal sclerosis (HS) and its potential role in predicting pharmacoresistance in temporal lobe epilepsy (TLE).

Methods

We included structural magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H‐MRS) metabolic data for 91 patients with unilateral TLE and 50 healthy controls. We measured the values of total N‐acetyl aspartate/total creatine (tNAA/tCr), glutamate/tCr (Glu/tCr), and myo‐inositol/tCr (mIns/tCr). To assess the influence of the pharmacoresponse and hemispheric‐side of HS on ...

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New‐onset acute symptomatic seizure and risk factors in Corona Virus Disease 2019: A Retrospective Multicenter Study

Summary

Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID‐19). This multicenter retrospective study enrolled people with COVID‐19 from 18 January to 18 February 2020 at 42 government‐designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had ...

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Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy

Abstract

The aim of this study was to investigate the influence of concomitant antiepileptic drugs (AEDs) on brivaracetam (BRV) trough serum concentrations. A total number of 368 routinely collected blood samples from 148 inpatients from Mara Hospital (Bethel Epilepsy Center) and von Bodelschwingh Foundation Bethel were retrospectively evaluated. Generalized estimation equations (GEEs) were used for statistical analysis. GEE analyses showed that BRV trough serum concentrations were significantly lower in patients with strong enzyme‐inducing AEDs (carbamazepine, phenytoin, and/or phenobarbital/primidone, −49%), but were ...

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Early developmental electroencephalography abnormalities, neonatal seizures, and induced spasms in a mouse model of tuberous sclerosis complex

Abstract

Objective

Tuberous sclerosis complex (TSC) is one of the most common genetic causes of epilepsy. Seizures in TSC typically first present in infancy or early childhood, including focal seizures and infantile spasms. Infantile spasms in TSC are particularly characteristic in its strong responsiveness to vigabatrin. Although a number of mouse models of epilepsy in TSC have been described, there are very limited electroencephalographic (EEG) or seizure data during the preweanling neonatal and infantile‐equivalent mouse periods. Tsc1
GFAPCKO mice are a well‐characterized ...

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Epilepsy in LAMA2‐related muscular dystrophy: An electro‐clinico‐radiological characterization

Abstract

Objective

To delineate the epileptic phenotype of LAMA2‐related muscular dystrophy (MD) and correlate it with the neuroradiological and muscle biopsy findings, as well as the functional motor phenotype.

Methods

Clinical, electrophysiological, neuroradiological, and histopathological data of 25 patients with diagnosis of LAMA2‐related MD were analyzed.

Results

Epilepsy occurred in 36% of patients with LAMA2‐related MD. Mean age at first seizure was 8 years. The most common presenting seizure type was focal‐onset seizures with or without impaired awareness. Visual aura and autonomic signs, including vomiting, were frequently ...

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