Accuracy of intracranial electrode placement for stereoencephalography: A systematic review and meta-analysis

Summary

Objective

Stereoencephalography (SEEG) is a procedure in which electrodes are inserted into the brain to help define the epileptogenic zone. This is performed prior to definitive epilepsy surgery in patients with drug-resistant focal epilepsy when noninvasive data are inconclusive. The main risk of the procedure is hemorrhage, which occurs in 1–2% of patients. This may result from inaccurate electrode placement or a planned electrode damaging a blood vessel that was not detected on the preoperative vascular imaging. Proposed ...

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Laser thermal ablation for mesiotemporal epilepsy: Analysis of ablation volumes and trajectories

Summary

Objective

To identify features of ablations and trajectories that correlate with optimal seizure control and minimize the risk of neurocognitive deficits in patients undergoing laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE).

Methods

Clinical and radiographic data were reviewed from a prospectively maintained database of all patients undergoing LiTT for the treatment of mTLE at the University of Miami Hospital. Standard preoperative and postoperative evaluations, including contrast-enhanced magnetic resonance imaging (MRI) and neuropsychological testing, were performed in all ...

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Self-management interventions in pediatric epilepsy: What is the level of evidence?

Summary

Objective

To respond to recommendations put forth by the Institute of Medicine to improve self-management resources for youth with epilepsy by conducting a systematic review of the self-management literature in pediatric epilepsy.

Methods

Inclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985–2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to “self-care” (pre-1996) and/or self-management (post-1996). ...

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Self-management interventions in pediatric epilepsy: What is the level of evidence?

Summary

Objective

To respond to recommendations put forth by the Institute of Medicine to improve self-management resources for youth with epilepsy by conducting a systematic review of the self-management literature in pediatric epilepsy.

Methods

Inclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985–2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to “self-care” (pre-1996) and/or self-management (post-1996). ...

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0

Self-management interventions in pediatric epilepsy: What is the level of evidence?

Summary

Objective

To respond to recommendations put forth by the Institute of Medicine to improve self-management resources for youth with epilepsy by conducting a systematic review of the self-management literature in pediatric epilepsy.

Methods

Inclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985–2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to “self-care” (pre-1996) and/or self-management (post-1996). ...

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0

Self-management interventions in pediatric epilepsy: What is the level of evidence?

Summary

Objective

To respond to recommendations put forth by the Institute of Medicine to improve self-management resources for youth with epilepsy by conducting a systematic review of the self-management literature in pediatric epilepsy.

Methods

Inclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985–2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to “self-care” (pre-1996) and/or self-management (post-1996). ...

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0

Carisbamate blockade of T-type voltage-gated calcium channels

Summary

Objectives

Carisbamate (CRS) is a novel monocarbamate compound that possesses antiseizure and neuroprotective properties. However, the mechanisms underlying these actions remain unclear. Here, we tested both direct and indirect effects of CRS on several cellular systems that regulate intracellular calcium concentration [Ca2+]i.

Methods

We used a combination of cellular electrophysiologic techniques, as well as cell viability, Store Overload-Induced Calcium Release (SOICR), and mitochondrial functional assays to determine whether CRS might affect [Ca2+]i levels through actions on the endoplasmic reticulum ...

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0

Self-management interventions in pediatric epilepsy: What is the level of evidence?

Summary

Objective

To respond to recommendations put forth by the Institute of Medicine to improve self-management resources for youth with epilepsy by conducting a systematic review of the self-management literature in pediatric epilepsy.

Methods

Inclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985–2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to “self-care” (pre-1996) and/or self-management (post-1996). ...

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0

Carisbamate blockade of T-type voltage-gated calcium channels

Summary

Objectives

Carisbamate (CRS) is a novel monocarbamate compound that possesses antiseizure and neuroprotective properties. However, the mechanisms underlying these actions remain unclear. Here, we tested both direct and indirect effects of CRS on several cellular systems that regulate intracellular calcium concentration [Ca2+]i.

Methods

We used a combination of cellular electrophysiologic techniques, as well as cell viability, Store Overload-Induced Calcium Release (SOICR), and mitochondrial functional assays to determine whether CRS might affect [Ca2+]i levels through actions on the endoplasmic reticulum ...

Seguir leyendo →
0

Carisbamate blockade of T-type voltage-gated calcium channels

Summary

Objectives

Carisbamate (CRS) is a novel monocarbamate compound that possesses antiseizure and neuroprotective properties. However, the mechanisms underlying these actions remain unclear. Here, we tested both direct and indirect effects of CRS on several cellular systems that regulate intracellular calcium concentration [Ca2+]i.

Methods

We used a combination of cellular electrophysiologic techniques, as well as cell viability, Store Overload-Induced Calcium Release (SOICR), and mitochondrial functional assays to determine whether CRS might affect [Ca2+]i levels through actions on the endoplasmic reticulum ...

Seguir leyendo →
0
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