Auditory processing following infantile spasms: An event-related potential study

Summary

Objectives

To investigate acoustic auditory processing in patients with recent infantile spasms (IS).

Methods

Patients (n = 22; 12 female; median age 8 months; range 5–11 months) had normal preceding development, brain magnetic resonance imaging (MRI), and neurometabolic testing (West syndrome of unknown cause, uWS). Controls were healthy babies (n = 22; 11 female; median age 6 months; range 3–12 months). Event-related potentials (ERPs) and psychometry (Bayley Scales of Infant Development, Second Edition, BSID-II) took place at a month ...

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Auditory processing following infantile spasms: An event-related potential study

Summary

Objectives

To investigate acoustic auditory processing in patients with recent infantile spasms (IS).

Methods

Patients (n = 22; 12 female; median age 8 months; range 5–11 months) had normal preceding development, brain magnetic resonance imaging (MRI), and neurometabolic testing (West syndrome of unknown cause, uWS). Controls were healthy babies (n = 22; 11 female; median age 6 months; range 3–12 months). Event-related potentials (ERPs) and psychometry (Bayley Scales of Infant Development, Second Edition, BSID-II) took place at a month ...

Seguir leyendo →
0

Auditory processing following infantile spasms: An event-related potential study

Summary

Objectives

To investigate acoustic auditory processing in patients with recent infantile spasms (IS).

Methods

Patients (n = 22; 12 female; median age 8 months; range 5–11 months) had normal preceding development, brain magnetic resonance imaging (MRI), and neurometabolic testing (West syndrome of unknown cause, uWS). Controls were healthy babies (n = 22; 11 female; median age 6 months; range 3–12 months). Event-related potentials (ERPs) and psychometry (Bayley Scales of Infant Development, Second Edition, BSID-II) took place at a month ...

Seguir leyendo →
0

Early discontinuation of antiseizure medications in neonates with hypoxic–ischemic encephalopathy

Summary

Objective

Neonates with hypoxic–ischemic encephalopathy (HIE) managed with therapeutic hypothermia (TH) often experience acute symptomatic seizures, prompting treatment with antiseizure medications (ASMs). Because the risk of seizure occurrence after hospital discharge is unknown, the optimal ASM treatment duration is unclear. We aimed to determine the risk of seizure occurrence after hospital discharge and the impact of ASM treatment duration on this outcome.

Methods

We performed a single-center, retrospective study of consecutive neonates with HIE managed with TH who received ...

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0

Early discontinuation of antiseizure medications in neonates with hypoxic–ischemic encephalopathy

Summary

Objective

Neonates with hypoxic–ischemic encephalopathy (HIE) managed with therapeutic hypothermia (TH) often experience acute symptomatic seizures, prompting treatment with antiseizure medications (ASMs). Because the risk of seizure occurrence after hospital discharge is unknown, the optimal ASM treatment duration is unclear. We aimed to determine the risk of seizure occurrence after hospital discharge and the impact of ASM treatment duration on this outcome.

Methods

We performed a single-center, retrospective study of consecutive neonates with HIE managed with TH who received ...

Seguir leyendo →
0

Early discontinuation of antiseizure medications in neonates with hypoxic–ischemic encephalopathy

Summary

Objective

Neonates with hypoxic–ischemic encephalopathy (HIE) managed with therapeutic hypothermia (TH) often experience acute symptomatic seizures, prompting treatment with antiseizure medications (ASMs). Because the risk of seizure occurrence after hospital discharge is unknown, the optimal ASM treatment duration is unclear. We aimed to determine the risk of seizure occurrence after hospital discharge and the impact of ASM treatment duration on this outcome.

Methods

We performed a single-center, retrospective study of consecutive neonates with HIE managed with TH who received ...

Seguir leyendo →
0

The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy

Summary

Objective

Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patterns of nonadherence in an animal epilepsy model.

Methods

In study 1, three different patterns of nonadherence were modeled in newly diagnosed epileptic rats treated with carbamazepine: perfect adherence (100% of pellets contained carbamazepine), ...

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The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy

Summary

Objective

Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patterns of nonadherence in an animal epilepsy model.

Methods

In study 1, three different patterns of nonadherence were modeled in newly diagnosed epileptic rats treated with carbamazepine: perfect adherence (100% of pellets contained carbamazepine), ...

Seguir leyendo →
0

The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy

Summary

Objective

Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patterns of nonadherence in an animal epilepsy model.

Methods

In study 1, three different patterns of nonadherence were modeled in newly diagnosed epileptic rats treated with carbamazepine: perfect adherence (100% of pellets contained carbamazepine), ...

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0

Source localization of ictal epileptic activity based on high-density scalp EEG data

Summary

Objective

Electrical source imaging (ESI) is a well-established approach to localizing the epileptic focus in drug-resistant focal epilepsy. So far, ESI has been used primarily on interictal events. Emerging evidence suggests that ictal ESI is also feasible and potentially useful. We aimed to investigate the diagnostic accuracy of ESI on ictal events using high-density electroencephalography (EEG).

Methods

We performed ictal ESI on 14 patients (9 with temporal lobe epilepsy) admitted for presurgical evaluation who presented seizures during a long-term ...

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