Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

This study was undertaken to describe a cohort of pediatric patients with status epilepticus (SE) in Italy over the past decade, focusing on the variability of treatment protocols among centers, adherence to guidelines, and potential predictors of refractoriness.

Methods

This is a multicenter retrospective observational cohort study including patients aged 1 month to 18 years who experienced convulsive SE (CSE) between January 2010 and June 2022. Variables analyzed included age at CSE onset, etiology, and treatment.

Results

We included 1374 CSE episodes in 1071 patients (median ...

Abstract

Objective

This study was undertaken to report on the long-term safety and efficacy of epicranial focal cortex stimulation (FCS) using the EASEE device as adjunctive neuromodulatory therapy in improving seizure control in adults with pharmacoresistant epilepsy originating from one predominant epileptogenic zone.

Methods

Prospective open-label follow-up of patients from the EASEE II and PIMIDES I clinical trials was done for a period of 2 years after the epicranial implantation of the EASEE electrode and stimulator device.

Results

Thirty-three patients underwent device implantation, and stimulation was activated ...

Abstract

Objective

Resting-state functional magnetic resonance imaging (rs-fMRI) at ultra-high field strengths (≥7T) is known to provide superior signal-to-noise to comparable acquisitions at lower field strengths. In this study, we provide a direct comparison of the seizure onset-zone (SOZ) lateralizing ability of 7T rs-fMRI and 3T rs-fMRI.

Methods

We investigated a cohort of 70 patients with temporal lobe epilepsy (TLE). A paired cohort of 19 patients had 3T and 7T rs-fMRI acquisitions for direct comparison between the two field strengths. Forty-three patients had only ...

Abstract

Objective

Focal epilepsy is caused by focal brain pathologies sometimes with involvement of surrounding or distant tissue. However, within the epileptogenic zone (EZ), which can be resected to cure epilepsy, the contribution of histopathological cells to epileptogenicity remains unknown. We hypothesized that areas showing neurophysiological biomarkers of epileptogenicity would more often contain histopathological cells compared to areas without such biomarkers.

Methods

Pediatric epilepsy patients with nonlesional magnetic resonance imaging (MRI), or with lesions with unclear borders, underwent stereoelectroencephalographic (SEEG) exploration followed by resective ...

Abstract

Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person-years adjusted for age and sex in women and men aged >60 years, respectively, compared to 18.1/100 000 in adults aged <60 years. In-hospital mortality associated with SE increases fourfold from the 3rd to 9th decade of life. There are multiple important ...

Abstract

Objective

In traditionally designed randomized clinical trials of antiseizure medications, participants take a blinded treatment for a prespecified number of weeks, irrespective of continued seizures. The alternative design time to prerandomization monthly seizure count (T-PSC) allows participants to end the blinded treatment after an individually prespecified number of seizures, which shortens exposure to placebo and ineffective treatment. Previous reanalyses have shown that T-PSC replicated the efficacy conclusions of trials; therefore, we evaluated whether T-PSC also could replicate tolerability and safety conclusions.

Methods

We ...

Abstract

Objective

The goal of this study was to investigate how the topographical map of human subjective experiences induced by intracranial electrical stimulation (iES) compares to the map of subjective auras experienced by patients during seizures involving the same cortical areas (here, the insular cortex).

Methods

We recruited 14 patients with insular epilepsies confirmed with intracranial electroencephalography in the United States (N = 7) and France (N = 7). We identified insular regions involved early in seizures (i.e., presumed seizure-onset zones [SOZs]), and documented the auras reported by ...

Abstract

Objective

This study was undertaken to determine the incidence of sudden unexpected death in epilepsy (SUDEP) in New Zealand.

Methods

We attempted to prospectively identify all people with epilepsy (PWE) in New Zealand who died from SUDEP after August 1, 2019. Information about the patients’ death and epilepsy was recorded in the EpiNet database. Two neurologists (P.S.B. and S.S.) reviewed each case and determined the SUDEP category. The national censuses for 2018 and 2023 were used as the denominator population.

Results

Records for 440 PWE ...