Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Abnormal patterns identified on electroencephalogram (EEG) are one of the primary diagnostic tests for epilepsy. However, epidemiological studies have established that both benign and epileptiform abnormalities (EA), occur in the EEG of non-epileptic, seizure-free people as well. The reported rates of EAs in non-epileptic, seizure-free populations vary, and the true prevalence is unknown. The primary objective of this systematic review and meta-analysis was to estimate the overall prevalence of EAs in the EEG of people without a history of seizures. ...

Abstract

In addition to the primary aim of seizure freedom, a key secondary aim of pediatric epilepsy surgery is to stabilize and, potentially, optimize cognitive development. Although the efficacy of surgical treatment for seizure control has been established, the long-term intellectual and developmental trajectories are yet to be delineated. We conducted a systematic review and meta-analysis of studies reporting pre- and postsurgical intelligence or developmental quotients (IQ/DQ) of children with focal lesional epilepsy aged ≤18 years at epilepsy surgery and assessed at ...

Abstract

Objective

The increasing implementation of electronic health records allows the use of advanced text-mining methods for establishing new patient-phenotypes and stratification, and for revealing outcome correlations. In this study we aimed to explore the electronic narrative clinical reports of a cohort of patients with Dravet Syndrome (DS) longitudinally followed at our center, to identify the capacity of this methodology to retrace natural history of DS during the early years.

Methods

We used a document-based clinical data warehouse employing Natural Language Processing to recognize ...

Abstract

Dravet Syndrome (DS) is a rare developmental and epileptic encephalopathy. Infants with DS are especially vulnerable to the detrimental effects of prolonged and frequent seizures on the development. Fenfluramine (FFA) is approved for the treatment of DS in patients from the age of 2 years and above.

This study aims to evaluate the safety and efficacy of FFA in patients with DS younger than 2 years of age.

We analyzed safety, tolerability, seizure and neuropsychological outcome in a real-world setting. Developmental profile was investigated ...

Abstract

Objective

Concern about climate change among the general public is acknowledged by surveys. The health care sector must play its part in reducing greenhouse gas emissions and adapting to a changing climate, which will require the support of its stakeholders including those with epilepsy, who may be especially vulnerable. It is important to understand this community’s attitudes and concerns about climate change and societal responses.

Methods

A survey was made available to more than 100 000 people among a section of the neurological community ...

Abstract

Objectives

Corpus callosotomy (CC) is used to reduce seizures, primarily in patients with generalized drug resistant epilepsy (DRE). The invasive nature of the procedure contribute to underutilization despite potential superiority to other palliative procedures. The goal of this study was to use a multi-institutional epilepsy surgery database to characterize the use of CC across participating centers.

Methods

Data was acquired from the Pediatric Epilepsy Research Consortium (PERC) Surgery Database, a prospective observational study collecting data on children 0-18 years referred for surgical evaluation of ...

Abstract

Objectives

To conduct external validation of previously published epilepsy surgery prediction tools using a large independent multicenter dataset and to assess whether these tools can stratify patients for being operated and for becoming free of disabling seizures (ILAE 1 and 2).

Methods

We analyzed a dataset of 1,562 patients, not used for tool development. We applied two scales: Epilepsy Surgery Grading Scale (ESGS) and Seizure Freedom Score (SFS), and two versions of Epilepsy Surgery Nomograms (ESNs): the original version and the modified version ...

Abstract

Objective

To assess reproducibility of the epilepsy outcome and phenotype in lateral fluid-percussion model of post-traumatic epilepsy across three study sites.

Methods

A total of 525 adult male Sprague-Dawley rats were randomized to lateral fluid-percussion -induced brain injury (FPI) or sham-operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43 sham, 221 TBI) and 261 for electrophysiological follow-up (EEG cohort, 41 sham, 220 TBI). A major effort was made to harmonize the rats, materials, equipment, procedures and monitoring systems. On ...

Abstract

Objective

Non-Hispanic (NH) Black children are less likely to receive a standard treatment course for infantile epileptic spasms syndrome (IESS) than White/NH children at pediatric tertiary care epilepsy centers in the United States. However, if inequities exist in time to diagnosis is unknown. Diagnostic delays as little as 1 week can be associated with worse developmental outcomes.

Methods

Diagnostic delays were evaluated in a retrospective cohort of 100 children with new onset IESS between January 2019 and May 2022.

Results

Children with Black, Indigenous, and ...