Abstract
Objective
Traumatic brain injury (TBI) may lead to the disruption of the intestinal barrier (IB), and to the escape of products of commensal gut bacteria, including lipopolysaccharide (LPS), into the bloodstream. We examined whether lateral fluid percussion injury (LFPI) and post‐traumatic epilepsy (PTE) are associated with the increased intestinal permeability and endotoxemia, and whether these events in turn are associated with PTE.
Methods
LFPI was delivered to adult male Sprague‐Dawley rats. Before, 1 week, and 7 months after LFPI, the IB permeability was ...
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