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Reflex seizures can be triggered by various stimuli, such as primary sensory stimuli and complex mental activities. Interestingly, accumulating evidence shows that playing specific games can trigger epileptic seizures, which are referred to as game-induced reflex epilepsy [1].
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The disruption of radial neuronal migration during brain development results in malformations composed of heterotopic grey matter (Barkovich et al., 2012). These may form continuous bands (laminar heterotopia) or discrete nodules, either in subcortical or periventricular locations (periventricular nodular heterotopia, PVNH). PVNH typically resides along the walls of the ventricular trigone, either unilaterally or bilaterally (Tassi et al., 2005). Nodular heterotopia is often associated with other types of cortical malformation, including polymicrogyria (PMG) (Wieck et al., 2005) and focal cortical ...
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SRI is supported by the Wellcome Trust Intermediate Clinical fellowship, the British Medical Association–Vera Down Research Grant and is part of the Oxford Epilepsy Research Group.
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Epilepsy is a common and chronic neurological disorder that imposes a substantial burden on individuals and society as a whole. The initial diagnosis of epilepsy is associated with costs of diagnostic procedures, inpatient admission and related loss of income [1,2]. Even after a first seizure or with newly established diagnosis of epilepsy, patients are affected by social stigma, reduced employment opportunities and impaired quality of life for themselves and their caregivers, resulting in increased indirect and intangible costs [3–8].
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Epilepsy is one of the most common neurological diseases worldwide [1]. The disease has an impact on the reproductive system. Males with epilepsy have lower fertility rates, hypo-sexuality and reduced potency in the population [2,3]. Establishing a direct connection between reduced fertility and epilepsy has been difficult [4–6]. Although reduced potency and sperm abnormalities were reported in some studies, the etiology is thought to be multifactorial [10–12]. Thus, the effects of anti-epileptic drugs on sex hormones and the reproductive system ...
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Epilepsy surgery is particularly effective in patients with type II focal cortical dysplasia (FCD), with a seizure freedom rate of up to 85% [1] that is probably due to an overlap between the anatomical lesion and the Epileptogenic Zone (EZ). In some cases, when the EZ is not properly identified, an invasive stereo-electro-encephalography (SEEG) may be required. During SEEG recordings, radiofrequency thermocoagulation (RF-THC) can be performed since there is increasing evidence that it can be beneficial to treat focal epilepsy ...
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