Seizure

High initial serum concentrations increase the risk of cutaneous adverse reactions. Genetic variants of the main metabolizing isoenzyme, uridine diphosphate glucuronosyltransferase (UGT) 1A4 influence the elimination of lamotrigine (LTG). Our aim was to investigate the potential association between the two best studied variants, *2 (P24T) and *3 (L48V), and the occurrence non-bullous skin reactions from LTG.

High initial serum concentrations increase the risk of cutaneous adverse reactions. Genetic variants of the main metabolizing isoenzyme, uridine diphosphate glucuronosyltransferase (UGT) 1A4 influence the elimination of lamotrigine (LTG). Our aim was to investigate the potential association between the two best studied variants, *2 (P24T) and *3 (L48V), and the occurrence non-bullous skin reactions from LTG.

In this editorial, the past chief-editors provide an account on how “Seizure, European Journal of Epilepsy” evolved from 2003 to 2010 into a truly “Made in Europe” clinical epilepsy journal with an international authorship and a global audience.

In this editorial, the past chief-editors provide an account on how “Seizure, European Journal of Epilepsy” evolved from 2003 to 2010 into a truly “Made in Europe” clinical epilepsy journal with an international authorship and a global audience.