Seizure

The disruption of radial neuronal migration during brain development results in malformations composed of heterotopic grey matter (Barkovich et al., 2012). These may form continuous bands (laminar heterotopia) or discrete nodules, either in subcortical or periventricular locations (periventricular nodular heterotopia, PVNH). PVNH typically resides along the walls of the ventricular trigone, either unilaterally or bilaterally (Tassi et al., 2005). Nodular heterotopia is often associated with other types of cortical malformation, including polymicrogyria (PMG) (Wieck et al., 2005) and focal cortical ...

SRI is supported by the Wellcome Trust Intermediate Clinical fellowship, the British Medical Association–Vera Down Research Grant and is part of the Oxford Epilepsy Research Group.

Epilepsy is a common and chronic neurological disorder that imposes a substantial burden on individuals and society as a whole. The initial diagnosis of epilepsy is associated with costs of diagnostic procedures, inpatient admission and related loss of income [1,2]. Even after a first seizure or with newly established diagnosis of epilepsy, patients are affected by social stigma, reduced employment opportunities and impaired quality of life for themselves and their caregivers, resulting in increased indirect and intangible costs [3–8].

Epilepsy is one of the most common neurological diseases worldwide [1]. The disease has an impact on the reproductive system. Males with epilepsy have lower fertility rates, hypo-sexuality and reduced potency in the population [2,3]. Establishing a direct connection between reduced fertility and epilepsy has been difficult [4–6]. Although reduced potency and sperm abnormalities were reported in some studies, the etiology is thought to be multifactorial [10–12]. Thus, the effects of anti-epileptic drugs on sex hormones and the reproductive system ...

Epilepsy surgery is particularly effective in patients with type II focal cortical dysplasia (FCD), with a seizure freedom rate of up to 85% [1] that is probably due to an overlap between the anatomical lesion and the Epileptogenic Zone (EZ). In some cases, when the EZ is not properly identified, an invasive stereo-electro-encephalography (SEEG) may be required. During SEEG recordings, radiofrequency thermocoagulation (RF-THC) can be performed since there is increasing evidence that it can be beneficial to treat focal epilepsy ...

Epilepsy is the most common serious neurological disorder in the UK with an estimated prevalence of between 0.7 and 0.8% [1,2]. The incidence is about 0.05% (50 per 1,000,000 population) per year [2] with incidence rates peaking in childhood and older age. Approximately 23% of people with epilepsy are women of child bearing age [3]. A population based study estimated that 0.33% of pregnancies involve active maternal epilepsy [4].

Compared to the general population, people with intellectual disabilities (ID) experience a disproportionate burden of illness, and are affected by twice the number of health issues [1–4]. Epilepsy is the most common neurological disorder in people with ID, with a reported prevalence of 22.2%, compared to 0.4% to 1% in the general population [2,5–10]. Epilepsy in people with ID can be more difficult to diagnose, more severe, and more difficult to treat than in the general population of people with ...

Compared to the general population, people with intellectual disabilities (ID) experience a disproportionate burden of illness, and are affected by twice the number of health issues [1–4]. Epilepsy is the most common neurological disorder in people with ID, with a reported prevalence of 22.2%, compared to 0.4% to 1% in the general population [2,5–10]. Epilepsy in people with ID can be more difficult to diagnose, more severe, and more difficult to treat than in the general population of people with ...

Seizure aggravation by antiepileptic drugs (AEDs) is increasingly recognized as a common problem, particularly in idiopathic generalized epilepsy (IGE). Benzodiazepines (BZDs) are one type of the main AEDs, especially in the treatment of status epilepticus. Paradoxical worsening of seizures associated with BZD is uncommon and most reports are among pediatric patients [1–3]. We report the case of an adult epilepsy patient with simple partial seizures that were aggravated or induced by BZDs.

Seizure aggravation by antiepileptic drugs (AEDs) is increasingly recognized as a common problem, particularly in idiopathic generalized epilepsy (IGE). Benzodiazepines (BZDs) are one type of the main AEDs, especially in the treatment of status epilepticus. Paradoxical worsening of seizures associated with BZD is uncommon and most reports are among pediatric patients [1–3]. We report the case of an adult epilepsy patient with simple partial seizures that were aggravated or induced by BZDs.