Seizure

As one of the most prevalent chronic neurological condition characterized by the recurrence of unprovoked seizures, epilepsy is afflicting seventy million people worldwide, with 50.4 per 100,000 people newly diagnosed every year [1]. In clinical practice, the final goal of epilepsy management is to help patients attain complete seizure freedom with the minimal side effects of antiepileptic drugs (AEDs) [2]. Previous studies have indicated that the high frequency of seizures before appropriate AEDs therapy, poor response to initial AEDs therapy, ...

Recurrent epileptic spells precipitate a number of crucial dangers during the attacks in patients with intractable epilepsy. Moreover, these patients suffer from neurocognitive dysfunction and medication side effects alongside their disease. There is a growing body of evidence revealing that seizures may result in aberrant neuronal plasticity in the originating zone after long-lasting attacks and consequently may lead to disfiguration of the natural synaptic structures [1–6].