Seizure

Epilepsy is an unpredictable, intrusive illness that impacts not only the patients but also those who care for them [1]. People with epilepsy (PWE) consistently report lower quality of life, higher levels of depression andanxiety [1]. Epilepsy could cause psychosocial distress, disrupt family routines and reorientthe interests and activities of family members.

Epilepsy is a group of neurological disorders characterized by recurrent epileptic seizures with a prevalence rate of 0.5%-1% among children [1]. Most patients are successfully treated with anti-epileptic drugs, but about a third suffer from treatment-resistant epilepsy (TRE) [2]. Vagal nerve stimulation (VNS), approved by U.S Food and Drug Administration (USFDA) in 1997, is a safe and efficacious treatment for TRE, consisting of an implanted pacemaker-like generator and nerve stimulation electrodes, that delivers intermittent stimulation to the patient’s left vagus ...

To evaluate the change in the number of female valproate users in Lithuania from 2013 to 2018 and determine the presumed impact of two distinct European Medicines Agency (EMA) regulatory interventions on the observed trend.

Stroke mimic (SM) is a set of conditions with clinical presentation similar to that of an acute ischemic stroke (AIS), albeit not caused by an ischemic event [1]. From 1% to 41% of patients presenting stroke-like symptoms at admission to the Emergency Department are actually SM [2]. The most common SM etiologies are seizure (38%), migraine with aura (37%), and conversion disorder (21%) [3]. Other conditions of SM are metabolic, infectious, neurodegenerative disorder, peripheral neuropathy and syncope [3].

A history of allergic drug reactions often limits the choice of medical treatment. These are reported in 10% of community case notes and for up to 35% of patients attending a US teaching hospital [1]. Current assessment of drug hypersensitivity in the UK relies on self-reporting. This is often misleading. In over 40% of cases, penicillin intolerance is incorrectly labeled as ‘allergy’ [2].

In 1628, Sir William Harvey, the famous English physician, stated that “For every affection of the mind that is attended with either pain or pleasure, hope or fear, is the cause of an agitation whose influence extends to the heart” [1]. In this article, we explore the interaction of brain and heart in patients with epilepsy, focusing on new insights into possible pathways from epilepsy, catecholaminergic toxicity, subtle cardiac changes and sudden death. Translational lessons from cardiac models of disease ...

Epilepsy surgery is an efficacious elective treatment for pharmacoresistant epilepsies [1,2]. Following comprehensive presurgical evaluation [3], patients are counseled with regard to the chances and risks of surgical treatment. This is essential for informed decision making [1]. At the University of Bonn Epilepsy Center which is conducting up to120 epilepsy surgeries per year since 1988 [4], a team of trained epileptologists explicitly estimates the individual chances of getting seizure free after surgery which is communicated to the patient (e.g.

SLC25A22 deficiency is a rare cause of familial and sporadic early onset developmental and epileptic encephalopathy (DEE) and epilepsy of infancy with migrating focal seizures (EIMFS) [1,2]. Patients typically present with refractory seizures, hypotonia, visual inattention with post-retinal dysfunction, microcephaly, neuroimaging abnormalities, burst-suppression pattern on EEG [1,2]. SLC25A22 is an important mitochondrial glutamate transporter in the liver and in the brain, it is highly expressed in astrocytes.

Juvenile myoclonic epilepsy (JME) is characterized by the presence of bilateral myoclonic, generalized myoclonic, tonic–clonic, and (less often) absence seizures. Its prevalence comprises 5–10% of all epilepsies and 18% of genetic (idiopathic) generalized epilepsies [1]. Clinical symptoms occur between 6 and 22 years of age, most frequently during adolescence: age at onset is 13–16 years in half of affected patients [2]. Myoclonic seizures primarily occur between 12 and 18 years of age; these consist of generalized tonic–clonic (GTC) seizures in ...

We aimed to identify clinical characteristics of patients with shoulder dislocations caused by an epileptic seizure.