Abstract
Objective
This study was undertaken to evaluate the real-world effectiveness and tolerability of first-line antiseizure medication (ASM) monotherapy in children with newly diagnosed epilepsy, focusing on comparative outcomes across developmental age groups and ASM types, and identifying clinical risk factors of treatment failure.
Methods
This retrospective cohort study analyzed 10 years of electronic medical records from Shenzhen Children’s Hospital. Children aged ≤18 years who initiated monotherapy with one of five ASMs (oxcarbazepine, valproate, levetiracetam, topiramate, or lamotrigine) were included. The primary outcome was treatment success, ...
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