Epilepsy is characterized by highly synchronized abnormal discharge of neuron groups. It is the most common neurological disease in children, and according to the World Health Organization, there were ∼50 million epilepsy patients worldwide in 2019 [1,2]. Epidemiological investigations showed that the prevalence of epilepsy in China was about 7.0‰ [2,3]. Anti-seizure medications (ASMs) remain the preferred choice for epilepsy treatment. In 2000, Kwan and Brodie reported in their prospective study that ∼47% of newly diagnosed epilepsy patients can achieve a seizure-free state with monotherapy [4].
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