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Infantile epileptic spasm syndrome (IESS) is the commonest developmental and epileptic encephalopathy of infancy with an average prevalence of 30 per 100,000. [1] It is associated with refractoriness to drugs, devastating developmental consequences and high-mortality. Mortality reached 31% each in a cohort of 214 children followed up for 20 to 35 years and 162 patients followed up for 60 months. [2,3] Sillanpaa and Riikonen have reported that 25 % died during a follow up spanning 17.2 years. [4] There are scarce new reports on mortality in IESS.